Scientist, Autoimmunity

A*STAR - Agency for Science, Technology and Research; Singapore; On-site; SGD 50,000 - 70,000; Full time

Benefits offered by this job

Access to state-of-the-art facilities

Dynamic research environment

Opportunities for mentorship

Job summary

A*STAR - Agency for Science, Technology and Research is looking for a motivated postdoctoral scientist in Singapore. You will lead research on immune tolerance related to autoimmunity, focusing on SLE and lupus nephritis.

The role involves in vivo experiments, flow cytometry, and multidisciplinary collaboration. A Ph.D. in Biomedical Sciences with specialisation in Immunology and strong publication history are required. Join a dynamic team to advance cutting-edge research in immune regulation.

Qualifications

• Ph.D. with Immunology specialization preferred.
• Strong track record in peer-reviewed publications.
• Experience in designing and executing experiments with technical rigor.

Responsibilities

• Investigate immune changes in SLE to lupus nephritis.
• Conduct in vivo mouse model experiments.
• Design and optimise flow cytometry experiments.

Skills

Understanding of immunology

Cell culture

Flow cytometry

Problem-solving skills

Communication skills

Education

Ph.D. in Biomedical Sciences/Engineering

Tools

Flowjo

R

Python

Job description

Overview

Lab of Immune Regulation, Resolution & Tolerance at Singapore Immunology Network (SIgN) seeks a motivated and interdisciplinary postdoctoral scientist to join our team in the field of autoimmunity. Successful candidate will lead and contribute to advancing our understanding of immune tolerance affected in autoimmunity, namely in Systemic Lupus Erythematosus (SLE) and lupus nephritis (LN). In particular, the candidate will explore myeloid and lymphocyte crosstalk during disease progression and investigate regulatory T cell deficits in SLE utilizing pre‑clinical mouse models, with opportunity to expand findings to human samples.

Key Responsibilities

• Investigate the dynamic changes in immune composition and cross‑talk during disease progression from SLE to lupus nephritis.
• Conduct in vivo mouse model experiments, including mouse breeding, handling, surgical procedures, end‑point sample harvesting, ensuring compliance with regulatory and ethical requirements.
• Design, perform, optimise, and analyse high‑parameter flow cytometry experiments across both mouse and human tissues.
• Conduct in vitro wet‑lab experiments, such as fluorescence‑activated cell sorting (FACS), cell‑culture of primary immune cells, immunofluorescence staining, among others.
• Handle and manage human clinical samples, ensuring compliance with regulatory and ethical requirements.
• Collaborate with others to set‑up and analyse large sequencing datasets including TCR‑sequencing and spatial transcriptomics.
• Analyse data using a combination of standard software including Flowjo (flow cytometry) and bioinformatics tools (R, Python).
• Provide mentorship and guidance to students and junior researchers in the lab.
• Engage and work closely with multidisciplinary team of collaborators across Singapore.
• Work closely with the PI to align research priorities and meet milestones.

Job Requirements

• Ph.D. in Biomedical Sciences/Engineering, with an Immunology specialization strongly preferred.
• Strong understanding of immunology, with key focus on autoimmunity.
• Strong track record of peer‑reviewed publications appropriate to current career stage.
• Experience in designing and executing experiments with a high degree of technical rigour. Familiarity with cell culture, primary immune cell isolation, and flow cytometry preferred.
• Familiarity with next generation sequencing, especially for spatial transcriptomics and TCR‑seq+scRNAseq is a plus.
• Excellent problem‑solving and critical thinking skills with the ability to work independently and collaboratively within a team.
• Strong written and oral communication skills, with experience in scientific publication and presentations.

Why Join Us

• Be part of a young and dynamic new team advancing research into immune tolerance and resolution.
• Gain experience working at the intersection of wet and dry lab with access to state‑of‑the‑art facilities and technologies.
• Perform rigorous science with strong translational capabilities.