Research Officer, Functional Genomics (GIS)

A*STAR RESEARCH ENTITIES; Singapore; On-site; SGD 42,000 - 62,000; Full time

Benefits offered by this job

Fully funded position

Professional development opportunities

Frontier lab technology access

International, interdisciplinary team

State‑of‑the‑art facilities

Job summary

The Genome Institute of Singapore (GIS, A*STAR) invites applications for a Research Officer specialized in molecular biology and cell model systems to join a new incoming laboratory. The role centers on establishing lab infrastructure and running experiments related to large‑scale functional genomics screens.

You will set up the lab, contribute to experimental design, and work alongside postdocs and PhD students, with collaboration across core facilities and external partners.

Qualifications

• Degree in biology or related field (BSc, MSc or equivalent).
• Solid hands‑on experience in molecular biology, cell culture, cell sorting and NGS library prep.
• Advantageous: single‑cell technologies, T cell isolation, 2D/3D cell models, pooled genetic screens.

Responsibilities

• Perform molecular biology experiments, library cloning, cell culture, cell sorting, and lentiviral transductions.
• Plan and run large‑scale genetic screens using single‑cell sequencing, imaging, and FACS.
• Contribute to experimental design, data analysis, and documentation with precise records.
• Manage orders, reagents, equipment, and ensure safe daily operations for the team.
• Support postdocs and PhD students and collaborate with core facilities and partners.

Skills

Molecular biology

Cell culture

Cell sorting

NGS library prep

Education

Biology degree

Tools

CRISPR/Cas9

Job description

The Genome Institute of Singapore (GIS, A*STAR) is the national flagship institute for genomic sciences in Singapore. We are recruiting a Research Officer specialized in molecular biology and cell model systems to join a new incoming laboratory. The new laboratory develops and applies technologies for large-scale functional genomics screens, combining single-cell multiomics with genetic perturbation tools (CRISPR/Cas9, deep mutational scanning) in complex disease models. The aim is to resolve at genome-wide scale how genetic changes affect cell function, and to use that knowledge to understand and treat complex diseases.

As one of the first hires, you will set up the laboratory and its infrastructure together with the incoming group leader, and then take a central role in running experiments and keeping the lab operating smoothly. You will contribute directly to research projects alongside postdocs and PhD students.

Job Description:

• Perform molecular biology experiments, library cloning, cell culture, cell sorting, and lentiviral transductions.
• Plan and run large-scale genetic screens using single-cell sequencing, imaging, and FACS.
• Contribute to experimental design and ideation, data analysis, and documentation, and keep accurate, timely records of materials, protocols, and results.
• Manage orders, reagents, and equipment, and ensure safe, smooth daily operations for the whole team.
• Support postdocs and PhD students on their projects, and work with the A*STAR core facilities and our academic and industry collaborators.

Requirements:

• A degree in biology or a related field (BSc, MSc, or equivalent) from a university or technical school. We consider candidates at all levels of their career.
• Required: solid hands‑on experience in molecular biology, cell culture, cell sorting, and next generation sequencing library preparation.
• Advantageous: single‑cell technologies, primary cells incl. T cell isolation and cultivation, 2D/3D cell model systems, pooled genetic screening, CRISPR/Cas9, and synthetic biology.
• You are proactive, well organized, and able to plan and manage several tasks in parallel.
• You have a collaborative working style, with clear communication and strong interpersonal skills.
• The position is on‑site.

What we offer

• A fully funded position with professional development opportunities.
• Work at the technology frontier on research that improves health for people in Singapore and beyond.
• A place in an international, interdisciplinary team of scientists at one of Asia's leading genomics institutes.
• Access to state‑of‑the‑art laboratory infrastructure and A*STAR core facilities.
• An initial contract of 2 years, with the possibility of renewal.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.