Research Fellow: Expansion Microscopy & Membrane Biology

NANYANG TECHNOLOGICAL UNIVERSITY; Singapore; On-site; SGD 70,000 - 120,000; Full time

Benefits offered by this job

Collaborative research environment

Job summary

The Lee Kong Chian School of Medicine (LKCMedicine) at NTU Singapore invites applications for a Research Fellow to lead a project on host and viral organelles using expansion microscopy and advanced imaging.

The role combines independent scientific direction with method development, quantitative image analysis, and mentoring of junior members, with opportunities to apply for external fellowships and to build collaborations within NTU and international partners.

Qualifications

• PhD in cell biology, structural biology, biochemistry, biophysics, bioengineering, molecular biology or a closely related discipline.
• A strong research track record with first-author publications.
• Extensive hands-on experience in advanced fluorescence microscopy including confocal and live-cell imaging.

Responsibilities

• Lead an independent line of research on the spatial organisation of host and viral organelles during infection, using expansion microscopy together with confocal, super-resolution and other advanced imaging approaches.
• Develop, validate and apply expansion microscopy and related sample-preparation workflows to host membrane compartments and pathogen-induced structures, helping to establish these as a robust capability within the laboratory.
• Investigate how protein lipidation (S-acylation) shapes membrane architecture, organelle contacts and compartment identity, using genetic, chemical and biochemical perturbation.
• Design and perform quantitative image analysis to extract structural and morphological measurements from large imaging datasets.
• Carry out cell culture, molecular biology, genome editing and infection experiments.
• Apply complementary biochemical, biophysical or structural approaches to support and extend the imaging work, as the questions of the project develop.
• Interpret results critically, contribute to the scientific direction of the project, and propose new experimental avenues.
• Prepare manuscripts, figures and presentations, present results at international meetings, and contribute to grant applications, including applications for the post-holder's own external fellowship funding.
• Supervise and mentor students at PhD, Master's and undergraduate level, and contribute to a collaborative and inclusive laboratory environment.
• Build and maintain collaborations within LKCMedicine and NTU, with imaging and other core facilities, and with international partners.
• Maintain rigorous experimental records, and ensure compliance with biosafety, risk assessment and institutional research governance requirements.

Skills

Fluorescence microscopy

Cell biology

Mammalian cell culture

Quantitative image analysis

Molecular biology

Live-cell imaging

Education

PhD in cell biology or related discipline

Tools

Expansion microscopy

Confocal microscopy

Image-analysis software

Scripting for image analysis

Job description

The Lee Kong Chian School of Medicine (LKCMedicine) at NTU Singapore invites applications for a Research Fellow to lead a project on host and viral organelles using expansion microscopy and advanced imaging.

The role combines independent scientific direction with method development, quantitative image analysis, and mentoring of junior members, with opportunities to apply for external fellowships and to build collaborations within NTU and international partners.