Process R&D and Project Engineer

WuXi AppTec; Singapore; On-site; SGD 64,000 - 86,000; Full time

Job summary

WuXi AppTec Singapore is seeking a lab-focused chemist to support R&D-to-production transfers. You will perform lab-scale tests, analyze spectra, and ensure GMP and safety compliance.

The role involves developing batch records, deploying DCS menus, and optimizing processes for higher yield and lower costs. The candidate should hold a related degree, have strong problem-solving and coordination skills, and be capable of independent work in a fast-paced environment.

Qualifications

• Must have a college degree or above in organic/ pharmaceutical chemistry or related fields.
• Proficient computer skills and data handling.
• Working knowledge of reaction mechanisms and key synthesis steps.
• Ability to perform NMR, HPLC, LCMS analyses with minimal supervision.
• Familiar with process diagrams and basic engineering concepts.
• Knowledge of mass and heat balance for chemical plants.
• Strong coordination, communication, and problem-solving abilities.

Responsibilities

• Conduct material use-tests in lab per process docs and compile test reports.
• Ensure compliance with GMP/EHS requirements and their implementation.
• Manage project transfers from R&D to factory with equipment selections.
• Participate in safety assessments and identify process hazards.
• Develop, review, and issue batch records and train production staff.
• Develop and deploy DCS process menus and review DCS data.
• Track progress, coordinate resources, resolve issues, and lead deviations.
• Select cleaning solvents and issue records for major equipment.
• Optimize large-scale production processes to improve quality and reduce costs.
• Review R&D reports, update master documents, and determine control strategies.
• Improve plant operating efficiency, yield, and energy conservation with field tests.
• Coordinate with process simulations and investigations for yield optimization.

Skills

Computer skills

Chemical reaction mechanisms

Spectra analysis (NMR, HPLC, LCMS)

Process & instrumentation diagrams

Mass & heat balance calculations

Coordination & communication

Problem-solving

Education

Bachelor's degree or above in chemistry/chem eng/related

Job description

• 1. College degree or above in Organic chemistry, Pharmaceutical Chemistry, Pharmaceutical Engineering, Chemical Engineering and Technology, Applied Chemistry, or other related majors.Fresh graduate are welcome
• 3. Skilled in computer；
• 4. Possesses a working knowledge of chemical reaction mechanisms and is proficient in chemical synthesis unit operations. Capable of independently, safely, and accurately executing key steps in the laboratory for various chemical reactions, including charging, in-process control (IPC), quenching, work-up, and crystallization.
• 5. Perform preliminary analysis of spectra such as NMR, HPLC, and LCMS with minimal supervision.
• 6. Basic engineering skill with utilizing process & instrumentation diagram.
• 7. Knowledge of mass and heat balance calculations of chemical plants
• 8. Good coordination and communication skills, High capacity of learning and execution, Strong problem-solving ability；

Responsibilities:

• 1. Conduct material use-test in the laboratory according to process documentation requirements, and perform lab-scale test during new supplier development. Capable of assessing compliance with production and process requirements, and independently compiling corresponding test reports.
• 2. Comply with the company's GMP/EHS requirements and ensure their effective implementation.
• 3. Manage the transfer of projects from R&D stage to factory, make reasonable equipment selections, ensure the smooth implementation of projects, and complete projects on time.
• 4. Participate in chemical safety assessments and process safety assessments, identify and control potential safety hazards in production processes.
• 5. Develop, review, and issue the batch records, conduct periodic training for production staff, and implement and track technological improvements for projects.
• 6. Develop and deploy DCS process menus, collect, print, and evaluate (if any) DCS data for production batches.
• 7. Track project progress, coordinate resources among departments, resolve issues identified during project production, lead deviation investigations, and take corrective and preventive measures.
• 8. Select appropriate cleaning solvents and issue cleaning records for major equipment.
• 9. Optimize large-scale and commercial production processes (if any) to improve product quality and operational efficiency, and reduce costs.
• 10. Review R&D reports, draft and update master process documents, conduct process validation, process transfers, and corresponding risk assessments, and determine control strategies and operating/acceptance ranges for critical process parameters (if any).
• 11. Optimize plant operating efficiency, yield optimization and energy conservation with feasibility study, make the necessary field test to verify the result.
• 12. Coordinate with technical section for process simulation, evaluation, investigation, performance & yield optimization.