Postdoctoral Scientist — Monoclonal Antibody Discovery

A*STAR - Agency for Science, Technology and Research; Singapore; On-site; SGD 60,000 - 90,000; Full time

Job summary

A*STAR Infectious Diseases Labs in Singapore is seeking a highly motivated Postdoctoral Research Fellow to develop next-generation antibody and receptor-based therapeutics against emerging pathogens.

The successful candidate will work on antibody discovery, protein engineering, virology, structural biology and translational infectious disease research, collaborating across disciplines and mentoring junior researchers.

Qualifications

• PhD in virology, immunology, structural biology, protein biochemistry, protein engineering, antibody engineering, microbiology, molecular biology, biotechnology, or a related discipline.
• Experience with monoclonal antibody isolation and characterization.
• Experience with co-IP/mass spectrometry for antigen identification.
• Highly motivated and able to work and learn independently.
• Team player with good interpersonal and communication skills.

Responsibilities

• Discover and characterize monoclonal antibodies from immune B cell libraries.
• Investigate antibody target antigens and epitopes through co-IP/mass spec.
• Investigate antibody target epitopes through mutagenesis, competition assays, structural approaches and/or computational analysis.
• Characterize antibody-antigen and receptor-virus interactions using techniques such as SDS-PAGE, ELISA, BLI/SPR or related methods.
• Design, express and characterize viral antigens, host receptors, antibody fragments and engineered receptor decoys to improve affinity, breadth, stability or resistance to viral escape.
• Work with collaborators across virology, structural biology, computational biology, animal models and translational development.
• Prepare manuscripts, presentations, patent disclosures and research proposals.
• Mentor junior researchers and contribute to the scientific development of the laboratory.

Job description

A*STAR Infectious Diseases Labs in Singapore is seeking a highly motivated Postdoctoral Research Fellow to develop next-generation antibody and receptor-based therapeutics against emerging pathogens.

The successful candidate will work on antibody discovery, protein engineering, virology, structural biology and translational infectious disease research, collaborating across disciplines and mentoring junior researchers.