Senior Scientist, Antibody Engineering & Biologics

A*STAR - Agency for Science, Technology and Research; Singapore; On-site; SGD 100,000 - 150,000; Full time

Job summary

A*STAR - Agency for Science, Technology and Research in Singapore seeks a Senior Scientist/Scientist for Antibody Engineering & Biologics to drive large molecule discovery from target hypotheses to differentiated, developable candidates.

The role emphasizes asset strategy, cross-functional collaboration, and development of future leadership in discovery, with a strong emphasis on integrative decision-making and external partner relevance.

Qualifications

• PhD in immunology, cancer biology, molecular biology, pharmacology, biotechnology, protein science or a related discipline.
• At least 5 years of relevant post-PhD experience in biologics, antibody discovery, translational research or drug discovery.
• Strong expertise in antibody discovery, characterisation and/or engineering is preferred.
• Experience working in multidisciplinary and cross-functional scientific teams, preferably within a drug discovery or translational research environment.
• Demonstrated ability to design, interpret and troubleshoot complex experiments.
• Ability to integrate biological and molecule-level data into clear experimental recommendations and programme decisions.
• Excellent communication and collaboration skills, with the ability to work effectively across scientific disciplines, functions and external partners.
• Product-minded discovery orientation, with an appreciation of how early scientific decisions influence candidate differentiation, developability and partnerability.

Responsibilities

• Translate target biology into clear biologics discovery hypotheses, desired molecule profiles, and candidate differentiation strategies.
• Act as an asset integrator across target biology, antibody discovery, antibody design, engineering, functional assays, translational studies and developability workstreams.
• Drive decision-enabling experiments that address the key biological, technical and product risks required for lead progression.
• Work closely with the Therapeutic Protein Antibody Discovery and Antibody Design groups to guide lead identification, optimisation, modality-fit assessment and molecule selection.
• Integrate multidisciplinary data to support lead nomination, go/no-go decisions, and discovery-stage proof-of-concept.
• Connect experimental outputs to the broader asset strategy, including candidate differentiation, competitive positioning, developability and partnerability.
• Identify emerging scientific risks, dependencies and bottlenecks and recommend practical mitigation plans or follow-up studies.
• Support preparation of partner-ready discovery packages, internal governance materials and external scientific narratives that clearly articulate asset value.
• Work with CROs, academic collaborators and technology partners where external capabilities are needed to advance the asset strategy.
• Build experience toward a future Discovery Project Leader role by contributing to scientific strategy, decision-making and cross-functional asset progression.

Skills

Antibody discovery

Protein engineering

Translational research

Biologics

Experiment design

Cross-functional teamwork

Data interpretation

Scientific communication

Education

PhD in relevant field

Tools

Lab automation

Bioinformatics tools

Statistical analysis

Job description

A*STAR - Agency for Science, Technology and Research in Singapore seeks a Senior Scientist/Scientist for Antibody Engineering & Biologics to drive large molecule discovery from target hypotheses to differentiated, developable candidates.

The role emphasizes asset strategy, cross-functional collaboration, and development of future leadership in discovery, with a strong emphasis on integrative decision-making and external partner relevance.