Lead Scientist: Purification & Process Development Expert

LONZA BIOLOGICS TUAS PTE. LTD.; Singapore; On-site; Confidential; Full time

Benefits offered by this job

Medical insurance

Transport from MRT to Tuas site

Career growth opportunities

Competitive compensation

Job summary

Lonza Singapore is seeking a Lead Scientist to guide purification development and characterization for downstream manufacturing processes of therapeutic proteins. You will provide scientific leadership, supervise DoE, and support regulatory submissions, ensuring timely project delivery.

The role requires 4–7 years of protein purification experience, strong writing skills, and collaboration across teams. There is a focus on safety, quality, and continuous improvement within a global biopharma

Qualifications

• Degree/PhD in Life Sciences or a related field, with relevant industry experience.
• 4–7 years’ experience in protein purification/process development; PhD candidates with 2–5 years’ experience may also be considered.
• Strong expertise in protein purification, with experience in Process Characterization.
• Experience with statistical software (e.g., JMP) for DoE data analysis is highly advantageous.
• Understanding of cGMP/BLA requirements is preferred.
• Strong technical writing, communication, problem-solving and analytical skills.
• Good team player with the ability to work collaboratively across projects.

Responsibilities

• Lead and oversee Process Development, Process Characterization, and/or Viral Clearance activities, including study planning, technical supervision, and interpretation of study outcomes.
• Drive small-scale model studies such as risk assessments (FMEA), scale-down model qualification, Design of Experiments (DoE), resin reuse/lifetime studies, and activities supporting regulatory submissions.
• Lead and support purification activities, including chromatography (Affinity, Mixed-Mode, and Ion Exchange) using ÄKTA/UNICORN systems, ultrafiltration/diafiltration (UF/DF), and viral reduction studies.
• Train and mentor junior scientists and new hires in the execution of laboratory activities, while providing training in purification technologies and laboratory techniques.
• Prepare and review high-quality protocols, reports, SOPs and technical documentation.
• Act as project representative for internal and external customer communication and coordinate multiple projects to ensure timely delivery.
• Provide scientific and technical support for manufacturing operations, troubleshooting activities, and technology transfer initiatives.
• Contribute to scientific excellence, operational improvements, safety and departmental training initiatives.

Skills

Protein purification

Process development

Team collaboration

Technical writing

Education

PhD in Life Sciences or related field

Tools

ÄKTA/UNICORN

JMP

Job description

Lonza Singapore is seeking a Lead Scientist to guide purification development and characterization for downstream manufacturing processes of therapeutic proteins. You will provide scientific leadership, supervise DoE, and support regulatory submissions, ensuring timely project delivery.

The role requires 4–7 years of protein purification experience, strong writing skills, and collaboration across teams. There is a focus on safety, quality, and continuous improvement within a global biopharma