iPSC Neuroglia Research Officer (ALS Models)

A*STAR - Agency for Science, Technology and Research; Singapore; On-site; SGD 42,000 - 66,000; Full time

Job summary

Institute of Molecular and Cell Biology (IMCB) in Singapore seeks a Research Officer to support iPSC-based models for glial cell biology and ALS-related projects in the Patani lab. You will participate from experimental design to validation and mechanistic studies, contributing to disease modelling efforts at A*STAR IMCB.

The role offers opportunities to work on disease-relevant cellular models, collaborate with scientists, and advance iPSC culture, differentiation, and biomolecular assays in a

Qualifications

• Bachelor’s or Master’s degree in biological sciences or related field.
• Laboratory experience in mammalian cell culture preferred.
• Experience with human pluripotent stem cell culture or differentiation advantageous.
• Familiarity with molecular biology, immunostaining, microscopy or cellular assays beneficial.
• CRISPR or neural/glial cell models experience is advantageous but not essential.
• Good laboratory organisation, record-keeping and troubleshooting skills.
• Able to work independently and in a team.

Responsibilities

• Culture, maintain and bank human iPSC lines with routine quality control and documentation.
• Differentiate iPSCs into neural and glial cell types including astrocytes, microglia and neurons.
• Support disease-relevant cellular models, including co-culture and organoid systems.
• Perform molecular, cellular, imaging and functional assays to characterise phenotypes.
• Support generation and characterisation of genetically modified or isogenic iPSC lines using CRISPR.
• Collect, organise and perform basic analysis of experimental data and maintain records.
• Assist with optimisation and troubleshooting of experimental protocols.
• Support general laboratory operations, inventory management and equipment maintenance.
• Work closely with scientists and research staff on ongoing projects.
• Maintain high standards of laboratory safety and good research practices.

Skills

Cell culture expertise

Stem cell differentiation

Molecular biology techniques

Immunostaining

Microscopy

CRISPR technologies

Data recording & troubleshooting

Independent and team work

Education

Bachelor’s or Master’s degree in Biological sciences

Tools

CRISPR

Job description

Institute of Molecular and Cell Biology (IMCB) in Singapore seeks a Research Officer to support iPSC-based models for glial cell biology and ALS-related projects in the Patani lab. You will participate from experimental design to validation and mechanistic studies, contributing to disease modelling efforts at A*STAR IMCB.

The role offers opportunities to work on disease-relevant cellular models, collaborate with scientists, and advance iPSC culture, differentiation, and biomolecular assays in a