ALS iPSC Scientist – Glial Biology & Neurodegeneration

A*STAR - Agency for Science, Technology and Research; Singapore; On-site; SGD 90,000 - 150,000; Full time

Job summary

Institute of Molecular and Cell Biology (IMCB) in Singapore is seeking a Scientist/Senior Scientist to develop and apply human iPSC-based models to study glial biology in neurological and neurodegenerative diseases in Prof. Patani's lab at A*STAR IMCB.

The role offers collaboration with wet and dry lab scientists, involvement in experimental design, target prioritisation, validation and mechanistic deconvolution, and opportunities to contribute to publications and proposals.

Qualifications

• PhD in stem cell biology, neuroscience, cell biology, molecular biology or a related discipline.
• Experience in human pluripotent stem cell culture and differentiation.
• Experience with iPSC-derived neural or glial models strongly preferred.
• Familiarity with astrocyte, microglial or oligodendrocyte biology advantageous.
• Experience with CRISPR, co-culture systems, imaging or single-cell analysis beneficial.
• Strong experimental, analytical and troubleshooting skills.
• Ability to work independently and collaboratively in a multidisciplinary research environment.

Responsibilities

• Generate and maintain human iPSC lines, including iPSC banking.
• Develop and optimise protocols for glial cell differentiation and neuronal cells.
• Establish disease-relevant cellular models, including co-culture or organoid systems.
• Perform molecular, imaging and functional assays to characterise glial phenotypes.
• Support generation of genetically modified or isogenic iPSC lines using CRISPR or similar technologies.
• Analyse experimental data, including transcriptomic or single-cell datasets where relevant.
• Work with multidisciplinary teams across neuroscience, genomics, imaging and computational biology.
• Contribute to publications, research proposals and scientific presentations.
• Support junior researchers and maintain high standards of laboratory practice.

Skills

CRISPR

co-culture

imaging

single-cell analysis

independence

collaboration

Education

PhD in stem cell biology or related

Tools

iPSC culture

neural/glial models

Job description

Institute of Molecular and Cell Biology (IMCB) in Singapore is seeking a Scientist/Senior Scientist to develop and apply human iPSC-based models to study glial biology in neurological and neurodegenerative diseases in Prof. Patani's lab at A*STAR IMCB.

The role offers collaboration with wet and dry lab scientists, involvement in experimental design, target prioritisation, validation and mechanistic deconvolution, and opportunities to contribute to publications and proposals.