Director / Senior Director, Clinical Development & Operations (Oncology) - Biopharma

Ethos BeathChapman; Singapore; On-site; SGD 180,000 - 280,000; Full time

Job summary

Ethos BeathChapman is seeking a senior leader to own the development execution of a first-in-portfolio oncology biologic, from IND through Phase I/II, in a founder-stage environment.

You will coordinate across clinical development, CROs, CDMOs, regulatory consultants, investigators, and management, with future opportunities as assets expand in the portfolio.

Qualifications

• 10–15+ years in clinical development or clinical operations.
• Owns development plans, challenges partners and maintains momentum.
• Strong Phase I/II oncology experience, including first-in-human studies.
• IND/CTA preparation and early clinical development experience.
• Proven CRO/vendor management track record across studies.
• Biologics experience preferred, biotech exposure ideal.
• English fluency; Mandarin proficiency for China coordination.
• Hands-on, accountable leader in a lean team.

Responsibilities

• Lead clinical operations and project execution from IND to Phase I/II.
• Manage CRO selection, study start-up, site activation, enrolment, data cleaning.
• Coordinate protocol development with management, investigators and regulatory teams.
• Drive cross-functional planning across clinical, regulatory, CMC, biomarker, safety and clinical supply.
• Act as primary interface with CDMOs, aligning manufacturing and clinical-supply timelines.
• Track critical-path risks and vendor performance, resolve issues proactively.
• Engage KOLs and investigators, provide concise updates to management.
• Help build scalable clinical and operational processes as the pipeline expands.

Skills

Clinical operations leadership

Oncology Phase I/II expertise

IND/CTA preparation

CRO/vendor management

Biologics experience

APAC/China development experience

English fluency

Mandarin proficiency

Job description

Own the development execution of a first-in-portfolio oncology biologic, from IND to Phase I/II, in a founder-stage environment.

The opportunity

You will lead execution of the biopharma’s first oncology asset, an innovative biologic entering IND-stage development. You will be the central coordinator across clinical development, CROs, CDMOs, regulatory consultants, investigators and management. As the portfolio grows, you will take on additional assets.

What you’ll do

• Lead clinical operations and project execution from IND preparation through Phase I/II
• Manage CRO selection, study start-up, site activation, enrolment, trial conduct and data cleaning
• Coordinate protocol development with management, investigators, medical advisors, biostatisticians and regulatory consultants
• Drive cross-functional planning across clinical, regulatory, CMC, biomarker, safety and clinical supply
• Act as the primary interface with CDMOs, aligning manufacturing and clinical-supply timelines
• Track critical-path risks and vendor performance, and resolve issues proactively
• Engage KOLs and investigators, and give management concise, decision-oriented updates
• Help build scalable clinical and operational processes as the pipeline expands

What you bring

• 10-15+ years in clinical development or clinical operations, ideally at Director or Senior Director level
• Experienced in owning the development plan, challenge partners, anticipate problems and keep the programme moving.
• Strong Phase I/II oncology experience, preferably including first-in-human studies
• IND/CTA preparation and early clinical development experience
• A strong track record managing CROs and complex vendor relationships
• Biologics experience strongly preferred
• Biotech experience, ideally paired with earlier time in larger pharma
• China/APAC clinical development experience, with global exposure preferred
• Fluency in English is required for cross-functional communication, and professional proficiency in Mandarin is required for direct communication, technical discussions and coordination with China-based biotech partners and clinical development stakeholders.
• A hands-on, detail-oriented style and comfort being the single point of accountability in a lean team

AM
Reg. No. R1110770
BeathChapman Pte Ltd
Licence no. 16S8112