Associate Principal Scientist - Biochemical Assay Development (all genders)

Overview

Associate Principal Scientist - Biochemical Assay Development (all genders) – Bayer, Wuppertal, North Rhine-Westphalia, Germany

As an Associate Principal Scientist - Biochemical Assay Development (all genders), you will work on innovative drug discovery projects and be an active member of highly interdisciplinary and cross-organizational research teams. With your expertise in biochemistry and cell biology, you will develop and implement tailored assay systems for data-driven decision-making. You will analyze key scientific questions in projects, create strategies and assays to link targets and modalities, and contribute to solving complex biological questions. Thanks to your experience and strategic thinking, you will make a crucial contribution to advancing research – driving medical progress and serving patients.

Responsibilities

• Your focus is on drug discovery projects and being an active member of highly interdisciplinary and cross-organizational teams
• Using your expertise in protein biology, you develop strategies to understand the links between targets and modalities, identify tailored lead finding approaches and develop relevant assay systems to probe target biology
• You develop biochemical assays for enzymes, protein-protein interaction and protein degradation
• You establish novel enzymatic readout cascades, analysis of enzyme kinetics and study of biophysical drug/protein interaction
• Identifying druggable entry points and relevant MoAs and establishing biochemical assays in high throughput formats (e.g. TR-FRET, FP) fall under your tasks
• Performing High Throughput Screens with robotic systems is part of your responsibility
• You critically assess key scientific questions in projects and develop and execute fit-to-purpose biological assays for data driven decision making
• You seamlessly collaborate with disease biologists, modality experts, drug discovery scientists and computational biologists to develop state-of-the-art methods and techniques to answer complex biological questions
• You keep up to date with the latest advances in assay development and drug discovery technologies by scouting innovation opportunities with external partners
• You engage with the broader scientific community through publications and conference presentations
• Supervising and mentoring lab associates, interns and postdocs to drive scientific projects are part of your function

Qualifications

• You have completed a PhD degree in Biochemistry or equivalent with post-graduate training in an industrial or academic environment
• You bring initial work experience and expertise in biochemical assay development (e.g. TR-FRET, Fluorescence Polarisation), and its application to complex biological problems in drug discovery
• You demonstrate a deep knowledge of enzymology, enzyme kinetics, protein/protein interaction assays
• Your experience in protein expression and production in eukaryotic, insect and bacterial cells contributes to your profile
• You have expert understanding of, and have worked with, a variety of biophysical methods like SPR, TSA, MS or MST
• Your knowledge of structural biology (X-Ray, cryoEM, alphafold, molecular modelling, etc.) is a plus
• You have hands-on experience with protein biology, structural biology, molecular biology and lab automation
• You exhibit broad knowledge of modalities available to address different targets
• You are digitally literate, with the ability to use digital analysis tools to effortlessly communicate with computational biologists and data scientists
• You are a strategic thinker with a strong interest for drug discovery, driven by the purpose of helping patients in need
• Your fluent English with excellent verbal, written communication and interpersonal skills to work across functions and within external collaborations rounds off your profile

Additional Information

This is a fixed-term contract for 24 months.

What We Offer

• We ensure your financial stability through a competitive compensation package, consisting of an attractive base pay and our annual bonus. In addition, managers can recognize special contributions by granting an individual performance award.
• Whether it’s hybrid work models or part-time arrangements: Whenever it is possible, you will have the flexibility to work how, when and where it is best for you.
• Your family is a top priority. We offer loving company daycare centers at multiple locations, support in finding childcare, time off for the care of elderly or dependent family members, summer camps for children, and much more.
• We support your professional growth by providing access to learning and development opportunities, training programs through the Bayer Learning Academy, development dialogues, as well as coaching and mentoring programs.
• We support your health and well-being with free check-ups by our company doctor, health seminars, and a wide range of initiatives that promote a healthy lifestyle.
• We embrace diversity by providing an inclusive work environment in which you are welcomed, supported, and encouraged to bring your whole self to work.

Be You. Be Bayer.

Location: Germany: North Rhine Westfalia: Wuppertal-Aprath

Division: Pharmaceuticals

Reference Code: 849654

Seniority level

• Mid-Senior level

Employment type

• Full-time

Job function

• Research, Analyst, and Information Technology

Industries

• Chemical Manufacturing, Pharmaceutical Manufacturing, and Biotechnology Research