Research Grant - P1230281

Euraxess; Coimbra; Hybride; EUR 13 000 - 17 000; Plein temps

Avantages offerts par ce poste

Financiamento pela FCT/ERDF

Regime de dedicação exclusiva

Résumé du poste

Universidade de Coimbra abre uma bolsa de pesquisa para o projeto “(Re)modelling of (Strategies) for (C)ircadian Rhythm and (G)ene Therapy in Fatal Familial Insomnia” no Centro CNC. Candidatos com mestrado em áreas relevantes devem cumprir requisitos legais e regulamentos RBI-UC e RBI-FCT para a bolsa de investigação.

A função decorre no Centro CNC de Neurociências e Biologia Celular e envolve atividades de investigação, supervisão e divulgação científica, com início previsto em outubro de 2026

Qualifications

• Mestre em Biologia/Biociências ou áreas correlatas, inscrito(a) num curso sem grau.
• Enquadramento nos regulamentos RBI-UC/RBI-FCT aplicáveis.
• Elegível para atribuição de bolsa segundo RBI-UC e RBI-FCT, conforme as regras.

Responsabilités

• Avaliar o impacto da insônia familiar fatal na regulação do sono usando técnicas de biologia molecular.
• Avaliar a acumulação de proteína PrP com RT-QuIC em tempo real e Western blot.
• Estudar o perfil lipídico do modelo in vitro e o lipídio plasmático de pacientes.
• Apresentar resultados em reuniões científicas e participar na divulgação científica, incluindo iniciativas públicas.

Connaissances

Técnicas de biologia molecular

Análise de dados

Comunicação científica

Formation

Mestrado em Biologia/ Biociências/ Ciências da saúde ou áreas relacionadas

Outils

Extração de RNA

Síntese de cDNA

qRT-PCR

Western blot

Imagem de Ca2+

Description du poste

Organisation/Company Universidade de Coimbra Department Divisão de Projetos e Atividades (Bolsas) Research Field Biological sciences » Other Researcher Profile First Stage Researcher (R1) Positions Master Positions Application Deadline 27 Oct 2026 - 23:59 (Europe/Lisbon) Country Portugal Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 14 Oct 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Reference Number IT137-26-346 Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The University of Coimbra opens a call for the assignment of a research grant, with one position(s), under the project COMPETE2030-FEDER-00698300_15868, title: “(Re)modelling of (Strategies) for (C)ircadian Rhythm and (G)ene Therapy in Fatal Familial Insomnia” .

The call is governed by this Notice of Opening, the University of Coimbra Research Grant Regulations (RBI-UC), subsidiarily by the Research Grant Regulations of the Foundation for Science and Technology (RBI-FCT), by the Research Fellow Statute (EBI), by the Norms for Grant Assignment and Management within R&D Projects, by the Code of Administrative Procedure (CPA), all in their current wording, and by other applicable national and community legislation.

Master’s degree holders, in the scientific area of Biology, Biochemistry, Health Sciences and related fields, enrolled in a non-degree-granting course [JB2] [JB3] .

I.II - The non-degree-granting course must be related to the type of activity covered by the grant. Non-degree-granting courses are defined as those referred to in subparagraph e) of paragraph 3 of Article 4 of Decree-Law No. 74/2006, in its current wording, provided that, under subparagraph e) of Article 3 of RBI-FCT, they are developed in association or cooperation between the higher education institution and one or more R&D units.

Candidates enrolled in non-degree-granting courses who have already benefited from a grant contract and who, with this grant assignment, including possible renewals, exceed a total accumulated period of two consecutive or non-consecutive years in this type of grant.

.

I.IV - Eligible for grant assignment if meeting the requirements:

a) Portuguese nationals or nationals of other EU Member States

b) Nationals of third countries

c) Stateless persons

d) Beneficiaries of political refugee status

II - Grant location:

CNC Center for Neuroscience and Cell Biology, University of Coimbra

III- Scientific supervision/coordination of the grant:

Ana Rita Alvaro

IV - Work Plan / Goals to be achieved:

1. To assess the impact of fatal familial insomnia on the dysregulation of sleep and the circadian rhythm by employing molecular biology techniques (RNA extraction, cDNA synthesis and qRT-PCR for clock genes) and evaluating sleep-related characteristics and functions using microelectrode system recordings and Ca²¿ imaging.

2. To assess the accumulation and propagation of prion protein using real-time RT-QuIC and Western blot.

3. To study the lipid profile of the in vitro model of fatal familial insomnia and the plasma lipidome profile of patients with fatal familial insomnia.

4. Presentations at scientific meetings and science communication, namely: organising and participating in the 15th Iberian Prion Congress in Coimbra; participating in science outreach activities aimed at the general public, such as the European Researchers’ Night, Rare Disease Day and World Sleep Day; and drafting a report at the end of the fellowship period.

V.I - Renewal Possibility:

Possibily renewable

VI - Funding and financial conditions of the grant

VI.I - Monthly grant amount (paid by bank transfer at the end of each month):

1359,64€

VI.II - Other financial components of the grant:

N.A.

VI.III -

In addition to the above amounts, voluntary social security (SSV) is included when the grant has a duration of six months or more, corresponding to the first level, if the candidate opts for it, as well as mandatory personal accident insurance.

VI.IV - Funding:

The grant(s) assigned under this call will be funded by Foundation for Science and Technology (FCT), I.P., through national funds and by the European Regional Development Fund (ERDF) through the Thematic Programme Innovation and Digital Transition (COMPETE 2030), under Portugal 2030, and by the European Union | Operation No. 15868 | COMPETE2030-FEDER-00698300_REACT-FF [LM7]

VI.V - Information and publicity about the funding:

In all R&D activities directly or indirectly funded by the grant — namely, in all communications, publications, and scientific outputs, as well as theses — carried out with the support provided by the grant, explicit reference must be made to the financial support of the Foundation for Science and Technology (FCT) and the European Regional Development Fund (ERDF), through the Innovation and Digital Transition Programme (COMPETE 2030) under Portugal 2030. [LM8]

VII - Selection Methods: Evaluation of the academic record (AR) – 100%

VII.I - AR

- In the evaluation of the academic record, the candidates' academic performance will be assessed according to the following weights and criteria:

Criterion 1 – Absolute merit of the CV – 50%

Criterion 2 – Specific knowledge related to the work plan – 40%

Criterion 3 – Oral or panel presentations at scientific meetings – 10%

VII.II- The evaluation of the criteria and the final classification will be based on a scale from 0 to 100, with scores rounded to the nearest hundredth, applying the following formulas:

- AR: criterion 1 * (50%) + criterion 2 * (40%) + criterion 3 * (10%) = 100

- Final Classification (FC): AR * (100%)

VII.III -

All candidates who meet the admission requirements are subject to the academic record evaluation, carried out according to the criteria and weights defined in VII.I.

VII.IV -

Candidates who score below 50 in any selection method will be excluded, and subsequent methods, if any, will not apply to them. Candidates who are duly notified but fail to attend the interview (if applicable) or withdraw at any stage will also be excluded.

VII.V -

Tie-breaking criteria: In the event of a tie in the rankings, candidates will be ordered in descending order as follows:

a) Based on the score obtained in the first method applied;

b) Based on the score of their academic qualifications.

VII.VI -

All provisional and final jury decisions must be justified, recorded in minutes, and published on https://apply.uc.pt/ .

VII.VII - Jury Composition:

VII.VIII- Selection reserve list:

The reserve list consists of candidates approved in all selection methods who do not secure one of the available vacancies under this procedure. The reserve list is valid for 6 months [LL9]

VIII- Application Submission

Candidates must access and register on the electronic platform https://apply.uc.pt/ to submit their application, selecting the procedure to which they wish to apply.

Documents uploaded for the application must be in portable document format (PDF).

Applications are submitted by completing the sections available in the electronic platform "Apply UC" under "My Application."

VIII.I- Mandatory documents to attach when applying:

• Curriculum Vitae, duly updated, dated, and signed;
• Copy of academic degree certificates.
• If the possession of a degree is a requirement for the grant, candidates holding a degree obtained abroad must, by the end of the application period, provide proof of recognition or evidence that it has been requested, as per Decree-Law No. 66/2018 of August 16. Failure to present degree recognition at the time of contract signing, as per the RBI-UC, will result in exclusion.
• If duly justified, documents proving the possession of academic degrees and diplomas, or their recognition, may be waived at the application stage and replaced by a candidate's sworn statement. However, until the grant agreement stage, the respective proofs must be submitted under penalty of exclusion.
• Proof of enrollment in a degree or non-degree course may be waived at the application stage and replaced by a sworn statement from the candidate. However, the required proof must be submitted by the grant agreement stage under penalty of exclusion.
• Whenever possible, documentation proving prior grant benefits should also be attached to the application.

VIII.II- Other documents to attach when applying:

• Any other elements the candidate considers relevant.

VIII.III -

All application documents must be submitted in Portuguese and/or English. When the originals are in another language, a translation into one of these languages must be provided.

VIII.IV -

Applications that are not properly completed or do not meet the admission criteria defined in the applicable legislation and this notice will not be accepted.

VIII.V -

No documents required for the application may be submitted after the application deadline.

VIII.VI -

Without prejudice to the penal provisions of the law, false statements made by candidates or grant holders regarding relevant matters for the grant award or renewal, or for the evaluation of its progress, will result in its cancellation.

X - Activity Regime:

The grant does not create or constitute a legal-labor relationship. It is carried out under an exclusive dedication regime, and the grantee is awarded the Research Grantee Status, as stipulated in the EBI and the RBI-UC.

XI - Notification of Candidates:

All notifications will be made through the electronic platform Apply UC , under the terms of subparagraph c) of paragraph 1 and subparagraph b) of paragraph 2 of Article 112 of the CPA and Article 22 of the RBI-UC. The notifications will take effect after being made, as provided in Article 113 of the CPA.

XII -

Under Articles 121 and 122 of the CPA and Article 22 of the RBI-UC, candidates may, if they wish, submit comments regarding the jury's decisions within 10 business days, through the "Audiência dos Interessados" option in the platform's procedure section.

XIII -

Candidates may also submit a complaint within 15 business days or an appeal to the UC's highest-ranking official within 30 business days, both following the respective notification, under Articles 191 and 192 of the CPA.

XIV -

Selected candidates must declare in writing, within five business days of notification, their acceptance of the grant and confirm that they meet the requirements to accept the proposed start date of the grant contract. Unless a justifiable reason is provided, failure to provide this declaration within the stipulated time will be considered a renunciation of the grant. In case of renunciation or withdrawal by the selected candidate, the next candidate on the final classification list will be notified.

XV -

The full competition process can be consulted by candidates, subject to prior scheduling, by sending an email to the Human Resources Management Service at: [e-mail] .

XVI -

In compliance with subparagraph h) of Article 9 of the Constitution, the University of Coimbra, as an employer, actively promotes a policy of equal opportunities between men and women in terms of employment access and career progression, ensuring that any form of discrimination is strictly avoided. It encourages underrepresented minorities in each area to apply.

Accordingly, no one may be privileged, benefited, disadvantaged, or deprived of any right or exempted from any duty on the grounds of ancestry, age, sexual orientation, gender, marital status, family status, economic situation, education, social origin or condition, genetic heritage, reduced work capacity, disability, chronic illness, nationality, ethnic origin or race, place of origin, language, religion, political or ideological beliefs, or trade union membership.

The University of Coimbra also promotes measures to facilitate the balance between professional, family, and personal life, recognizing the efforts of its employees and fostering motivation.

XVII-

The grantee must submit annual activity reports for each renewal and at the end of the grant contract, as stipulated in Article 7 of the RBI-UC, subject to an opinion issued by the respective supervisor(s). The report models, performance evaluation criteria, and the grant contract model are those approved under the University of Coimbra's Research Grant Regulations.