PhD in Liver Organoid Disease Modeling (3-year, 100%)

Runar Almaas; Oslo fylke; On-site; NOK 520,000 - 620,000; Full time

Benefits offered by this job

100% position for three years

Ambitious project and interesting科学主题

Emerging research area

Training in advanced methods and tools

International environment

Favorable pension and welfare

Equal opportunities policy

Job summary

Oslo University Hospital offers a 3-year, 100% PhD position in the Department of Pediatric Research, Rikshospitalet. The project focuses on neonatal cholestasis using iPSC-derived liver organoids to study disease mechanisms and potential therapies.

The candidate will be supervised by Professor Runar Almaas and co-supervisor Barbora Smolkova, with work conducted in an international, collaborative environment; documentation and reporting in English or Scandinavian languages are required.

Qualifications

• Master degree in medicine, biomedicine, biotechnology, or molecular biology.
• Experience with extraction, quantification, and analysis of nucleic acids (DNA/RNA) and proteins, including qRT-PCR, ddPCR, and Western blotting.
• Experience in cell cultivation and handling; knowledge of molecular biology techniques, including gene editing and sequencing, is advantageous.
• Good written and oral English communication skills.

Responsibilities

• Reveal mechanisms of cholestasis and pruritus using iPSC-derived liver organoids.
• Study protein trafficking, factors modulation, and potential drugs in organoid models.
• Collaborate with engineers and scientists in a team and communicate findings effectively.

Skills

Nucleic acid analysis

qRT-PCR

ddPCR

Western blotting

English (writing)

Education

Master's degree in medicine/biomedicine/biotechnology or molecular biology

Tools

CRISPR/Cas9

Next-generation sequencing

Job description

Oslo University Hospital offers a 3-year, 100% PhD position in the Department of Pediatric Research, Rikshospitalet. The project focuses on neonatal cholestasis using iPSC-derived liver organoids to study disease mechanisms and potential therapies.

The candidate will be supervised by Professor Runar Almaas and co-supervisor Barbora Smolkova, with work conducted in an international, collaborative environment; documentation and reporting in English or Scandinavian languages are required.