PhD Position

Runar Almaas; Oslo fylke; On-site; NOK 520,000 - 620,000; Full time

Benefits offered by this job

100% position for three years

Ambitious project and interesting科学主题

Emerging research area

Training in advanced methods and tools

International environment

Favorable pension and welfare

Equal opportunities policy

Job summary

Oslo University Hospital offers a 3-year, 100% PhD position in the Department of Pediatric Research, Rikshospitalet. The project focuses on neonatal cholestasis using iPSC-derived liver organoids to study disease mechanisms and potential therapies.

The candidate will be supervised by Professor Runar Almaas and co-supervisor Barbora Smolkova, with work conducted in an international, collaborative environment; documentation and reporting in English or Scandinavian languages are required.

Qualifications

• Master degree in medicine, biomedicine, biotechnology, or molecular biology.
• Experience with extraction, quantification, and analysis of nucleic acids (DNA/RNA) and proteins, including qRT-PCR, ddPCR, and Western blotting.
• Experience in cell cultivation and handling; knowledge of molecular biology techniques, including gene editing and sequencing, is advantageous.
• Good written and oral English communication skills.

Responsibilities

• Reveal mechanisms of cholestasis and pruritus using iPSC-derived liver organoids.
• Study protein trafficking, factors modulation, and potential drugs in organoid models.
• Collaborate with engineers and scientists in a team and communicate findings effectively.

Skills

Nucleic acid analysis

qRT-PCR

ddPCR

Western blotting

English (writing)

Education

Master's degree in medicine/biomedicine/biotechnology or molecular biology

Tools

CRISPR/Cas9

Next-generation sequencing

Job description

3-year 100% PhD position is available at the Department of Pediatric Research, OUS Rikshospitalet for a highly motivated and skilled PhD student on a project funded by South-Eastern Norway Regional Health Authority. The position is available from 23rd November 2026.

Neonatal cholestasis is a condition with impaired bile flow causing accumulation of bile acids and bilirubin, liver damage and debilitating pruritus. Reduction in bile to the intestine results in malabsorption, reduced weight gain, vitamin deficiency and changes in microbiota. Both genetic and environmental factors can result in cholestasis.

About the Department / Research Group

Professor Runar Almaas (Pediatric hepatology) at PFI, OUS is leading the project. The PhD candidate will be supervised by him and by Co-supervisor Barbora Smolkova (PhD) and senior researcher Gareth Sullivan. The group is using induced pluripotent stem cells for making liver organoids and a major part of the work will be related to this model.

Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and we encourage all qualified candidates, regardless of background, to apply!

Duties and responsabilities

What Tasks and Responsibilities Are Associated with the Position?

To reveal mechanisms of cholestasis and pruritus and to investigate novel potential treatments we are using liver organoids derived from disease-specific induced pluripotent stem cells. iPSC-derived liver organoids are a unique model that can mimic key features of the human liver and can be used to study liver development and disease. In these project liver organoids will be used for studying protein trafficking, effect of modulating factors and potential drugs.

Qualifications

• Master degree (or equivalent) in medicine, biomedicine, biotechnology, or molecular biology
• Good practical skills in various extraction, quantification, and analysis of nucleic acids (DNA and RNA) and proteins including qRT-PCR, ddPCR, and Western blotting are advantages
  
• Skills and prior experience in cell cultivation and handling is an advantage
  experience in other relevant molecular biology techniques including gene editing using CRISPR/Cas9 technology, next-generation sequencing, etc is an advantage
  
• Experience in scientific writing / presentation is an advantage
  
• Good written and oral communication skills in English

Practical Information

We request that relevant documentation be attached to the application. Please note that all documents should be in English or a Scandinavian language.

Personal qualities

• We are looking for a highly dedicated, reliable and highly motivated candidate with great working capacity
  
• We expect scientific curiosity and understanding about the nature of scientific thinking
  
• You have a strong interest in completing your tasks in structured way.
  
• You are able to design, plan, perform, and analyze experiments in an innovative way
  
• The candidate is expected to work together with engineers and other scientists in a team. Ability to work independently, but with good communication skills is preferred.

We can offer

• 100% position for three years granted
• Ambitious project and interesting scientific topic.
  
• An emerging and rapidly developing area of research
  
• Training in advanced methods and models.
  
• Encouraged supervision and cooperation team
  
• A friendly and international environment
  
• A favorable pension arrangement and attractive welfare arrangements
  
• In accordance with the OUS's equal opportunities policy, we invite applications from all interested individuals regardless of gender or ethnicity

Kontaktinformasjon

Runar Almaas,Head of Department,[phone]

Arbeidssted

Sognsvannsveien 20
0372Oslo

Nøkkelinformasjon:

Arbeidsgiver: Oslo universitetssykehus HF
Referansenr.: 5194655530
Stillingsprosent: 100%
Contract
Startdato: 23.11.2026
Sluttdato: 09.11.2029
Søknadsfrist: 15.11.2026