PhD Position

Department of Pediatric Research, Oslo University Hospital; Oslo fylke; Presencial; NOK 520.000 - 600.000; Jornada completa

Descripción de la vacante

Department of Pediatric Research at Oslo University Hospital invites applications for a 3-year full-time PhD position focused on neonatal cholestasis using induced pluripotent stem cell-derived liver organoids. You will be supervised by Professor Runar Almaas and colleagues, aiming to reveal disease mechanisms and potential treatments.

The role demands a strong background in molecular biology, cell culture, and gene editing, with excellent English communication, and a passion for rigorous

Formación

• Master degree in medicine, biomedicine, biotechnology, or molecular biology.
• Practical skills in extraction, quantification, and analysis of nucleic acids (DNA/RNA) and proteins including qRT-PCR, ddPCR, and Western blotting are advantages.
• Skills and prior experience in cell cultivation and handling; experience with gene editing using CRISPR/Cas9 and next-generation sequencing is an advantage.
• Experience in scientific writing / presentation is an advantage.
• Good written and oral communication skills in English.

Responsabilidades

• Reveal mechanisms of cholestasis and pruritus using iPSC-derived liver organoids.
• Study protein trafficking, drug effects, and modulation factors in liver organoid models.
• Collaborate with engineers and other scientists in a team, while able to work independently.

Conocimientos

Cell culture

qPCR

ddPCR

Western blot

CRISPR/Cas9

NGS

Scientific writing

English communication

Educación

Master's degree in life sciences

Herramientas

CRISPR/Cas9

Descripción del empleo

Department of Pediatric Research, Oslo University Hospital

3-year 100% PhD position is available at the Department of Pediatric Research, OUS Rikshospitalet for a highly motivated and skilled PhD student on a project funded by South-Eastern Norway Regional Health Authority. The position is available from 23rd November 2026.

Neonatal cholestasis is a condition with impaired bile flow causing accumulation of bile acids and bilirubin, liver damage and debilitating pruritus. Reduction in bile to the intestine results in malabsorption, reduced weight gain, vitamin deficiency and changes in microbiota. Both genetic and environmental factors can result in cholestasis.

About the Department / Research Group

Professor Runar Almaas (Pediatric hepatology) at PFI, OUS is leading the project. The PhD candidate will be supervised by him and by Co-supervisor Barbora Smolkova (PhD) and senior researcher Gareth Sullivan. The group is using induced pluripotent stem cells for making liver organoids and a major part of the work will be related to this model.

Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and we encourage all qualified candidates, regardless of background, to apply!

Duties and responsabilities

What Tasks and Responsibilities Are Associated with the Position?

To reveal mechanisms of cholestasis and pruritus and to investigate novel potential treatments we are using liver organoids derived from disease-specific induced pluripotent stem cells. iPSC-derived liver organoids are a unique model that can mimic key features of the human liver and can be used to study liver development and disease. In these project liver organoids will be used for studying protein trafficking, effect of modulating factors and potential drugs.

Qualifications

• Master degree (or equivalent) in medicine, biomedicine, biotechnology, or molecular biology
• Good practical skills in various extraction, quantification, and analysis of nucleic acids (DNA and RNA) and proteins including qRT-PCR, ddPCR, and Western blotting are advantages
• Skills and prior experience in cell cultivation and handling is an advantage experience in other relevant molecular biology techniques including gene editing using CRISPR/Cas9 technology, next-generation sequencing, etc is an advantage
• Experience in scientific writing / presentation is an advantage
• Good written and oral communication skills in English

Practical Information

We request that relevant documentation be attached to the application. Please note that all documents should be in English or a Scandinavian language.

Personal qualities

• We are looking for a highly dedicated, reliable and highly motivated candidate with great working capacity
• We expect scientific curiosity and understanding about the nature of scientific thinking
• You have a strong interest in completing your tasks in structured way.
• You are able to design, plan, perform, and analyze experiments in an innovative way
• The candidate is expected to work together with engineers and other scientists in a team. Ability to work independently, but with good communication skills is preferred.

We can offer

• 100% position for three years granted
• Ambitious project and interesting scientific topic.
• An emerging and rapidly developing area of research
• Training in advanced methods and models.
• Encouraged supervision and cooperation team
• A friendly and international environment
• A favorable pension arrangement and attractive welfare arrangements
• In accordance with the OUS’s equal opportunities policy, we invite applications from all interested individuals regardless of gender or ethnicity

Kontaktinformasjon

Runar Almaas, Head of Department, [phone]

Arbeidssted

Sognsvannsveien 20
0372 Oslo

Nøkkelinformasjon

Arbeidsgiver: Oslo universitetssykehus HF

Referansenr.: 5194655530

Stillingsprosent: 100%

Contract

Startdato: 23.11.2026

Sluttdato: 09.11.2029

Søknadsfrist: 15.11.2026

Om bedriften

Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.

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