Senior Scientist – Large Libraries & Protein Screening

Cradlebio; Amsterdam; On-site; EUR 85,000 - 135,000; Full time

Benefits offered by this job

Competitive salary

Equity stake

Career progression opportunities

Job summary

Cradle is seeking a (Senior) Scientist to join the Large Libraries team in Amsterdam, driving high-throughput screening for protein-protein interactions. You will develop novel methods to screen variant libraries and generate large-scale data powering Cradle's AI/ML platform across biotech applications.

You will lead cross-functional projects, collaborate with ML to define data needs, and contribute to advancing the Cradle platform in a fast-paced startup environment.

Qualifications

• PhD in biochemistry, molecular biology, biophysics, synthetic biology, bioengineering, or related field.
• Invented or substantially adapted workflows in method development.
• Excitement to learn, contribute, and drive innovation in an early stage startup.
• Strong verbal and written communication in English.
• Ability to run multiple projects while keeping data organized.

Responsibilities

• Develop and optimize novel workflows for high-throughput protein-protein interaction library screening.
• Build and optimize in vitro or cell-based assay pipelines across multiple display modalities (yeast, phage, mRNA, ribosome display, or mammalian display).
• Design, build, and execute molecular biology and biochemistry frameworks for library construction, screening, and data generation at scale.
• Establish robust and repeatable assays with the statistical rigor required for ML model training, evaluation and optimization.
• Drive and lead projects from experimental design through data delivery.
• Identify opportunities to improve throughput, data quality, repeatability, and workflow efficiency.
• Partner with the ML team to define data requirements and integrate experimental outputs into the ML pipeline.
• Communicate results, insights, and technical challenges across disciplines.
• Contribute to shaping the scientific direction of the Large Libraries team and meaningfully contribute to the Cradle platform.

Skills

English communication

Project management

Education

PhD in biochemistry, molecular biology or related field

Tools

FACS

NGS (Illumina)

Python

R

Job description

Cradle is seeking a (Senior) Scientist to join the Large Libraries team in Amsterdam, driving high-throughput screening for protein-protein interactions. You will develop novel methods to screen variant libraries and generate large-scale data powering Cradle's AI/ML platform across biotech applications.

You will lead cross-functional projects, collaborate with ML to define data needs, and contribute to advancing the Cradle platform in a fast-paced startup environment.