Senior VHH Nanobody Discovery & Engineering Scientist

Cortalix BV

Groningen

Hybrid

EUR 65,000 - 90,000

Full time

14 days+

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Benefits offered by this job

Employee stock option plan

Job summary

Cortalix BV in Groningen, The Netherlands, is seeking an experienced Scientist – VHH Nanobody Discovery & Engineering to contribute to the discovery, optimization and characterization of next-generation VHH nanobodies for internal programs and international client projects.

The role covers phage display, ribosomal or mRNA display, library design, affinity maturation, expression and purification, and the integration of AI-assisted sequence analysis, automation and robotic workflows across diverse

Qualifications

Hands-on VHH experience essential and ability to contribute to discovery & engineering activities.
PhD or equivalent in a relevant life science field with several years of practical VHH/nanobody experience.
Experience with VHH library construction, screening and/or selection methods.
Experience in recombinant protein expression, purification and characterization.
Strong cloning and protein engineering skills; familiarity with AI-supported workflows is a plus.

Responsibilities

Lead discovery and optimization of VHH nanobodies for internal programs and client projects.
Design and optimize immune and synthetic nanobody libraries.
Perform affinity maturation and characterization using experimental and in silico approaches.
Develop and implement recombinant expression in bacterial, yeast, and cell-free systems; purify and characterize proteins.
Apply binding analysis (ELISA, SPR, BLI) and use FACS and cell-based assays as needed.
Contribute to integrating AI, NGS-guided selection and automation into workflows.