Senior VHH Nanobody Discovery & Engineering Scientist

Cortalix BV; Groningen; Híbrido; EUR 65.000 - 90.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Employee stock option plan

Descripción de la vacante

Cortalix BV in Groningen, The Netherlands, is seeking an experienced Scientist – VHH Nanobody Discovery & Engineering to contribute to the discovery, optimization and characterization of next-generation VHH nanobodies for internal programs and international client projects.

The role covers phage display, ribosomal or mRNA display, library design, affinity maturation, expression and purification, and the integration of AI-assisted sequence analysis, automation and robotic workflows across diverse

Formación

• Hands-on VHH experience essential and ability to contribute to discovery & engineering activities.
• PhD or equivalent in a relevant life science field with several years of practical VHH/nanobody experience.
• Experience with VHH library construction, screening and/or selection methods.
• Experience in recombinant protein expression, purification and characterization.
• Strong cloning and protein engineering skills; familiarity with AI-supported workflows is a plus.

Responsabilidades

• Lead discovery and optimization of VHH nanobodies for internal programs and client projects.
• Design and optimize immune and synthetic nanobody libraries.
• Perform affinity maturation and characterization using experimental and in silico approaches.
• Develop and implement recombinant expression in bacterial, yeast, and cell-free systems; purify and characterize proteins.
• Apply binding analysis (ELISA, SPR, BLI) and use FACS and cell-based assays as needed.
• Contribute to integrating AI, NGS-guided selection and automation into workflows.

Conocimientos

VHH discovery

Protein engineering

Molecular biology

English communication

AI/NGS workflows

Educación

PhD in Molecular Biology

Herramientas

Phage display

Ribosomal display

mRNA display

ELISA

SPR

BLI

Descripción del empleo

Cortalix BV in Groningen, The Netherlands, is seeking an experienced Scientist – VHH Nanobody Discovery & Engineering to contribute to the discovery, optimization and characterization of next-generation VHH nanobodies for internal programs and international client projects.

The role covers phage display, ribosomal or mRNA display, library design, affinity maturation, expression and purification, and the integration of AI-assisted sequence analysis, automation and robotic workflows across diverse