Senior Scientist, High-Throughput Protein Libraries (Remote)

Cradle; Amsterdam; Hybrid; EUR 85,000 - 110,000; Full time

Job summary

Cradle is seeking a (Senior) Scientist to join the Large Libraries team in Amsterdam to drive high-throughput screening capabilities for protein-protein interactions and to generate large-scale datasets powering our AI/ML platform.

You will develop novel workflows, lead projects, and collaborate with ML and biology teams to advance protein design and optimization across biotechnology applications.

Qualifications

• PhD in biochemistry, molecular biology, biophysics, synthetic biology, bioengineering, or a related field.
• Demonstrated creativity in method development: invented or substantially adapted workflows, not just executed established ones.
• Excitement to learn, contribute, and drive innovation in an early stage startup environment. Be comfortable with ambiguity and a fast paced environment.
• Strong verbal and written communication skills in English. Proactively sharing results, successes and challenges in a cross-functional environment.
• Ability to run multiple projects simultaneously while ensuring that process steps are documented, and physical/digital data are organized.

Responsibilities

• Develop and optimize novel workflows for high-throughput protein-protein interaction library screening
• Build and optimize in vitro or cell-based assay pipelines across multiple display and screening modalities (yeast, phage, mRNA, ribosome display, or mammalian display)
• Design, build, and execute molecular biology and biochemistry frameworks for library construction, screening, and data generation at scale
• Establish robust and repeatable assays with the statistical rigor required for ML model training, evaluation and optimization
• Drive and lead projects from experimental design through data delivery
• Identify opportunities to improve throughput, data quality, repeatability, and workflow efficiency.
• Collaborate with a cross-functional team to troubleshoot complex technical challenges and iterate on solutions.
• Partner with the ML team to define data requirements and integrate experimental outputs into the ML pipeline.
• Communicate results, insights, and technical challenges effectively across disciplines.
• Contribute to shaping the scientific direction of the Large Libraries team and meaningfully contribute to the advancement of the Cradle platform.

Job description

Cradle is seeking a (Senior) Scientist to join the Large Libraries team in Amsterdam to drive high-throughput screening capabilities for protein-protein interactions and to generate large-scale datasets powering our AI/ML platform.

You will develop novel workflows, lead projects, and collaborate with ML and biology teams to advance protein design and optimization across biotechnology applications.