Senior Research Associate: LNP Conjugation & Biologics

Vertex Pharmaceuticals LLC; Leiden; On-site; EUR 67,000 - 101,000; Full time

Benefits offered by this job

Medical benefits

Dental and vision

Paid time off

Educational assistance

Commuting subsidy

401(k)

Job summary

Vertex is seeking a talented Senior Research Associate to join a collaborative Bioconjugation team in Boston, focused on lipid nanoparticle (tLNP) conjugation and purification. In this lab‑based role, you will execute and optimize lab workflows, analyze data, and contribute to platform development with independent initiative.

You should bring hands‑on experience with conjugation strategies, DLS, HPLC, and related assays, and be prepared to present results in oral and written formats in Vertex’s

Qualifications

• Hands on experience in various conjugation strategies.
• Preferred experience in Antibody drug conjugates or Antibody oligonucleotide conjugation.
• Proficiency in LNP characterization techniques such as DLS and HPLC.
• Experience with tangential flow filtration and sterile filtration.
• Ability to present results in both oral and written formats.

Responsibilities

• Execute routine conjugations of ligands, scaffolds, and peptides to LNPs.
• Develop, optimize, and troubleshoot tLNP conjugation and purification processes.
• Analyze tLNP attributes using DLS, Ribogreen assays, HPLC, and related methods.
• Plan experiments and conduct work with limited supervision as required.
• Maintain records, prepare summaries, and present findings to the team.
• Support platform development and documentation related to conjugation.

Skills

Conjugation strategies

tLNP conjugation

DLS

HPLC

Antibody drug conjugates

Education

Bachelor's degree in biological sciences

Master's degree (or equivalent)

Tools

TFF (Tangential Flow Filtration)

Sterile filtration

RiboGreen assay

Job description

Vertex is seeking a talented Senior Research Associate to join a collaborative Bioconjugation team in Boston, focused on lipid nanoparticle (tLNP) conjugation and purification. In this lab‑based role, you will execute and optimize lab workflows, analyze data, and contribute to platform development with independent initiative.

You should bring hands‑on experience with conjugation strategies, DLS, HPLC, and related assays, and be prepared to present results in oral and written formats in Vertex’s