Principal LNP Formulation & Analytics Lead

Vertex Pharmaceuticals Inc (US); Leiden; On-site; EUR 80,000 - 120,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Comprehensive benefits

Job summary

Vertex Pharmaceuticals is seeking a Principal Research Associate to join the LNP Discovery team. The role focuses on formulating, purifying, and analyzing LNPs from small to large scale, collaborating with colleagues across disciplines in a fast-paced drug development environment.

The candidate will drive DoE-enabled method development, optimize yields, and advance formulation conditions. A strong background in LNP analytics and manufacturing for non-human primate studies is preferred.

Qualifications

• Master’s degree in chemistry, pharmaceutical science, chemical engineering, biochemistry, or related field with 5+ years of industry experience.
• Alternatively, a bachelor’s in those fields with 7+ years of industry experience.
• Experience with DoE-driven method development and LNP analytics.

Responsibilities

• Formulate, purify, and analyze LNPs at small- and large-scale using standard protocols.
• Run LNP analytics (size, cargo encapsulation, pKa, osmolality, endotoxin) and maintain ELN records.
• Develop and optimize DoE-driven formulation and process development to improve yield and scalability.
• Present experimental designs and data in cross-functional meetings.

Skills

LNP formation

Microfluidic mixing

DoE method development

LNP analytics

Analytical techniques

Education

Master’s degree in Chemistry/Pharma/Engineering

Bachelor’s degree in Chemistry/Pharma/Engineering

Tools

TFF purification

LC-MS

Mixer systems operation

Job description

Vertex Pharmaceuticals is seeking a Principal Research Associate to join the LNP Discovery team. The role focuses on formulating, purifying, and analyzing LNPs from small to large scale, collaborating with colleagues across disciplines in a fast-paced drug development environment.

The candidate will drive DoE-enabled method development, optimize yields, and advance formulation conditions. A strong background in LNP analytics and manufacturing for non-human primate studies is preferred.