Protein Engineer II - Antibody Ligand Discovery

ThermoFisher Scientific; Leiden; On-site; EUR 65,000 - 90,000; Full time

Job summary

Thermo Fisher Scientific in Leiden, Netherlands, seeks a Scientist II with a strong background in protein engineering to develop next-generation affinity ligands for biologics purification. You will design and execute protein-engineering experiments, screen antibody fragments, and work closely with cross-functional R&D teams to advance early discovery through development.

You will apply computational and AI-enabled tools, analyze complex datasets, and contribute to project planning and

Qualifications

• MSc or PhD in molecular biology, biochemistry, or related life-sciences.
• Experience in protein engineering, preferably in biotech or applied academic research.
• Experience planning, executing and interpreting experiments independently.
• Strong attention to detail and lab safety protocols.
• Excellent written and verbal English communication; Dutch is a plus.
• Working knowledge of Dutch is considered an advantage.

Responsibilities

• Design and execute protein-engineering experiments to improve ligand performance.
• Apply computational protein engineering, structural modeling, bioinformatics, and AI tools to support design.
• Screen and characterize antibody fragments using display technologies.
• Analyze large datasets to identify trends and guide iterative engineering cycles.
• Coordinate experimental activities and track progress within workstreams.
• Collaborate with multidisciplinary R&D teams and share knowledge.
• Stay informed about scientific developments to strengthen the antibody-engineering platform.

Skills

Protein engineering

Molecular biology

Biochemistry

Data analysis

Project collaboration

English communication

Dutch language (advantage)

Education

MSc or PhD in Molecular Biology / Biochemistry

BSc with antibody engineering experience

Tools

Phage display

Yeast display

SPR

BLI

FPLC

Automated liquid handling

Job description

Thermo Fisher Scientific in Leiden, Netherlands, seeks a Scientist II with a strong background in protein engineering to develop next-generation affinity ligands for biologics purification. You will design and execute protein-engineering experiments, screen antibody fragments, and work closely with cross-functional R&D teams to advance early discovery through development.

You will apply computational and AI-enabled tools, analyze complex datasets, and contribute to project planning and