Postdoctoral researcher in Neurobiology Multiple Sclerosis

Werkenbijumcg; Groningen; On-site; EUR 42,000 - 54,000; Full time

Job summary

University Medical Center Groningen is seeking a junior Postdoc with a PhD in molecular cell biology to join a neuroscience-focused project on decoding MS lesion evolution. You will integrate multi-omics data and region-specific RNA sequencing to link signaling changes with lesion progression and remyelination outcomes.

We value an enthusiastic, highly motivated researcher with a flexible attitude and strong English communication skills.

Qualifications

• PhD in molecular cell biology or related field required.
• Enthusiastic, highly motivated, talent for neuroscience research.
• Fluent written and spoken English, good communication skills.

Responsibilities

• Contribute to decoding region-distinct differences in signaling and regulatory networks in MS lesions.
• Integrate global proteomic, phosphoproteomic, and long-read RNA sequencing data.
• Collaborate within a team and present results clearly to project stakeholders.

Skills

Neuroscience

Bioinformatics

Team collaboration

Education

PhD in molecular cell biology

Job description

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system characterized by neuroinflammation and neurodegeneration. Current disease-modifying therapies are non-curative and do not reverse progression. On the level of tissue, MS lesion progression is prevented by remyelination, a natural regeneration process after demyelination that is crucial for functional recovery and neuronal survival. In this project, you will build further on our research aimed at deciphering MS lesion evolution by decoding region-distinct differences in cellular signaling and regulatory networks. You will generate and integrate global proteomic and phosphoproteomic signatures of MS lesion rims and cores in parallel with region-specific long-read RNA sequencing. This will allow you to link changes in signaling networks and RNA- and protein isoforms to molecular processes involved in lesion expansion and lesion transition. This multi-omics data approach will further the functional disentangling of molecular and cellular pathways underlying ongoing demyelination in lesion rims and successful remyelination or remyelination failure in lesion cores. The novel layer of changes in RNA and protein diversity will advance our understanding of MS and may thereby identify novel therapeutic targets.The position is funded by Stichting MS Research.

A junior Postdoc with a PhD degree in molecular cell biology or a related field. We are looking for an enthusiastic, highly motivated and talented postdoctoral researcher with affinity for neuroscience and a strong scientific drive. Expertise with bioinformatic analysis is an advantage. Furthermore, you will need a flexible working attitude, team player mentality, good oral and written communication skills in English, and a result-driven and pro-active attitude.