Postdoc: Osteogenesis Imperfecta Bone-on-Chip Scientist

Amsterdam UMC; Amsterdam; On-site; EUR 42,000 - 65,000; Full time

Benefits offered by this job

Public transport reimbursement

Bike scheme

BeFrank pension

8.3% end-of-year bonus

Job summary

Amsterdam UMC Research BV in Amsterdam seeks a highly motivated postdoctoral researcher to advance a human Bone-on-Chip model for Osteogenesis Imperfecta. You will validate and implement the BBoC platform using human bone explants to study remodeling and fracture healing, with translational pharma testing in partnership with Azafaros.

The role emphasizes rigorous experimental design, interdisciplinary collaboration with clinicians and engineers, and hands-on work with osteoclasts and osteoblasts

Qualifications

• PhD in biomedical sciences, bio-engineering, (molecular) medicine or a closely related field.
• Strong experience with advanced cell culture; experience with primary human cells and/or bone or other tissue explants is a strong advantage.
• An affinity with bone biology and bone remodelling, including osteoblasts and osteoclasts, or a clear motivation to specialise in this area.
• Experience with biological read-outs, such as RT-PCR, imaging, immunocytochemistry or histology; experience with organ-on-chip or microfluidic models is an asset.
• Strong experimental planning and troubleshooting skills, with the ability to carefully standardise and document protocols.

Responsibilities

• Validate and implement the BBoC technology using human bone explants.
• Study bone remodelling and fracture healing under controlled in vitro conditions.
• Design and perform preclinical experiments with a pharmaceutical compound, including dose-finding and longitudinal read-outs.
• Collaborate with clinicians, basic scientists and engineers to translate organ-on-chip data into patient-relevant insights.

Skills

PhD in Biomed Sci

Advanced cell culture

Bone biology

Osteoclasts/osteoblasts

Organs-on-chip

Education

PhD in Biomedical Sciences

Job description

Amsterdam UMC Research BV in Amsterdam seeks a highly motivated postdoctoral researcher to advance a human Bone-on-Chip model for Osteogenesis Imperfecta. You will validate and implement the BBoC platform using human bone explants to study remodeling and fracture healing, with translational pharma testing in partnership with Azafaros.

The role emphasizes rigorous experimental design, interdisciplinary collaboration with clinicians and engineers, and hands-on work with osteoclasts and osteoblasts