Experienced Analytical Chemistry Technician - in vitro Metabolism

Charles River Laboratories, Inc.; 's-Hertogenbosch; Remote; EUR 34,000 - 52,000; Full time

Benefits offered by this job

29.5 holidays

Extra holidays

8% holiday pay

Company bonus

Travel allowance

Bicycle lease

Pension plan

Fitness membership

Free fruit

Job summary

Charles River Laboratories, Den Bosch is seeking an Experienced Analytical Chemistry Technician - in vitro Metabolism to join the in vitro metabolism team. You will perform LC-MS/MS studies, develop and validate methods, and contribute to research in a modern lab environment.

The role requires a relevant HBO/HLO degree, at least 2 years' LC-MS/MS experience, and strong Dutch and English communication. A hands-on, proactive problem-solver attitude is essential for success in this

Qualifications

• Relevant applied science degree (HBO/HLO) in analytical chemistry or biochemistry.
• Minimum 2 years’ experience with LC-MS/MS, including method development and validation.
• Interest in identifying unknown compounds and using data analysis software (Xcalibur, Compound Discoverer, Empower, MassLynx).
• Strong communication skills in Dutch and English.
• Hands-on, creative problem-solving attitude.
• Proactive, results-driven, and flexible personality.

Responsibilities

• Perform in vitro metabolism studies from sample pre-treatment to LC-MS/MS analysis.
• Develop and validate study setups and research new approaches.
• Work in a renovated laboratory with state-of-the-art analytical equipment.

Skills

Dutch language proficiency

English language proficiency

Problem solving

Team collaboration

Education

Applied science degree (HBO/HLO) in analytical chemistry or biochemistry

Tools

LC-MS/MS

Xcalibur

Compound Discoverer

Empower

MassLynx

Job description

Select how often (in days) to receive an alert:

Experienced Analytical Chemistry Technician - in vitro Metabolism

Location:

Den Bosch (S-Hertogenbosch), NL, 5231 DD

For 75 years, Charles River employees have worked to advance the discovery, development, and safe manufacture of new drug therapies, making a profound impact on global health. Our 20-year partnership with Boston Children’s Hospital takes this mission to the next level, supporting groundbreaking innovations that directly impact patient care. At Boston Children’s, their commitment to diversity drives the exceptional quality of care provided to patients from local communities to over 160 countries worldwide. This is your moment to become part of a family where unique talents and perspectives unite to change lives, including your own. Together, we’re shaping a healthier future through compassion, innovation, and opportunity.

Job Overview

Join our in vitro Metabolism Team in Den Bosch and take on a role with a wide variety of tasks and responsibilities. At Charles River Laboratories Den Bosch we are currently hiring a:

Experienced Analytical Chemistry Technician - in vitro Metabolism

About us: At Charles River Laboratories, we help make the world a safer place by studying the behavior of substances before they reach the market. These substances include medicines, (agro)chemicals, and food ingredients, Our Discovery & Environmental Sciences department consists of about 90 talented professionals working on diverse projects for clients worldwide. Characteristic of the work is the great diversity of tests, test substances, customers and collaborations.

About the team:Within the Discovery & Environmental Sciences department, you’ll join our in vitro metabolism section, a dynamic group that investigates how compounds are processed in the body and interact with biological processes. We test these compounds in various studies using in vitro models including hepatocytes, blood and plasma. The chemical analysis of these compounds is performed using mass spectrometry (LC-MS) to quantify them in biological materials. For some studies, we identify unknown metabolites using high-resolution LC-MS instruments, requiring complex scientific problem-solving.

Our team consists of 9 study directors (scientific project managers) and 13 technicians. We work in an open, informal and flexible culture where collaboration and mutual support are key, and innovation is actively encouraged.

Job Description

About your role:

As an experienced technician, you’ll play a key role in performing a wide range of in vitro metabolism studies.

You will perform various in vitro metabolism studies from sample pre-treatment, method development, implementation and sample analysis with LC-MS/MS. Next to the study work, you are involved in researching, developing and validating of new study setups.

You will be working in a recently renovated laboratory (2021) equipped with new state-of-the‑art analytical equipment.

Your profile:

• A relevant applied science degree (HBO/HLO) in analytical chemistry or biochemistry
• Minimal 2 years’ experience with LC-MS/MS, including method development and validation
• Interest in identifying unknown compounds and using data analysis software (e.g., Xcalibur, Compound Discoverer, Empower and Masslynx)
• Strong communication skills in Dutch and English.
• A hands‑on, creative problem‑solving attitude.
• Proactive, results‑driven, and flexible personality.

Nice to have:

• Familiarity with biological test systems or biological materials
• Certification to work with radioactive materials
• Knowledge of Good Laboratory Practice (GLP)

Our offer:

Ongoing training and support and;

• 29.5 holidays on a full‑time basis;
• Possibility to purchase 10 additional holidays per year;
• Annual one‑off 8% holiday pay of your gross annual salary;
• Annual one‑off payment based on company results;
• Travel allowance at €0.23 cents per kilometer with a maximum of €250 net per month or an NS Business Card;
• Bicycle (lease) plan;
• Collective pension with a own contribution of 2.9%;
• Company fitness membership;
• Free fresh fruit every day.

The salary for this position, based on a 40‑hour work week, ranges from €33.696 to €51.800 gross per year. The final salary offer will depend on factors such as your experience, skills, education, and location

Physical Requirements

About Insourcing Solutions

Charles River Insourcing Solutions can streamline research by delivering operational and cost efficiencies through the strategic insourcing of GMP, GLP and non‑GLP research services from discovery through safety assessment. Insourcing Solutions provides you with the ability to maintain control of your facility and expertise while leveraging available space.

About Charles River

Charles River is an early‑stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non‑GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.

At Charles River we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well‑being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years.

We’re committed to providing benefits that elevate your quality of life. Based on your position these may include: bonus/incentives based on performance, 401K, paid time off, stock purchase program, Health and wellness coverage, employee and family wellbeing support programs, and work life balance flexibility.

Charles River is an equal opportunity employer and is committed to providing equal employment opportunities for all qualified applicants and employees without regard to race, color, sex, religion, national origin, ancestry, age, mental or physical disability, family status, pregnancy, military or veteran status, or any other characteristic protected by federal, state, or local laws.

It is unlawful in some states (including Massachusetts) to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to [e-mail]. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

For more information, please visit www.criver.com.

Job Segment: Chemical Research, Testing, Pharmaceutical, Plasma, Network, Engineering, Technology, Science