Technologist position - 3D Chromatin and non-coding RNAs

European Commission; Italia; In loco; EUR 40.000 - 50.000; Tempo pieno

Descrizione del lavoro

The European Commission seeks a researcher in biological sciences focused on non-coding RNAs and genome architecture at the Istituto Italiano di Tecnologia. This role involves advanced molecular biology techniques and collaboration within a diverse team. Candidates should have extensive lab experience and a PhD. Competitive salary and bonuses available.

Servizi

Flexible working time

Wide range of staff discounts

Potential tax deduction for eligible candidates

Competenze

• Extensive experience in molecular biology, biochemistry, genetics or cell biology.
• Previous experience in producing NGS data such as ChIP-seq, RNA-seq, ATAC-seq.
• Experience with cell culture maintenance.

Mansioni

• Using advanced molecular biology techniques for RNA, DNA, and protein manipulation.
• Collaborating with lab members to implement CRISPR technologies.
• Writing research articles and assisting in grant proposals.

Conoscenze

Good publication record

Strong command of spoken and written English

Ability to work independently

Ability to work collaboratively

Formazione

PhD in Cellular/Molecular Biology, Biochemistry or similar

Strumenti

CRISPR technologies

Descrizione del lavoro

Organisation/Company Istituto Italiano di Tecnologia Research Field Biological sciences Neurosciences Researcher Profile Recognised Researcher (R2) Country Italy Application Deadline 31 Jul 2025 - 00:00 (UTC) Type of Contract Other Job Status Other Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Project: “Exploring the role of non-coding RNAs in 3D chromatin Hubs” – Acronym: 3D-Hubs – Grant Agreement number: FIS-2023-02410 – CUP: J53C24004180001

Contract: Fixed-term contract, full time

Duration: up to 3 years

Step into a world of endless possibilities, together let’s leave something for the future!

At IIT, we are committed to advancing human-centered Science and Technology to address the most urgent societal challenges of our era. We foster excellence in both fundamental and applied research, spanning fields such as neuroscience and cognition, humanoid technologies and robotics, artificial intelligence, nanotechnology, and material sciences, offering a truly interdisciplinary scientific experience. Our approach integrates cutting-edge tools and technology, empowering researchers to push the limits of knowledge and innovation. With us, your curiosity will know no bounds.

We are dedicated to providing equal employment opportunities and fostering diversity in all its forms, creating an inclusive environment. We value the unique experiences, knowledge, backgrounds, cultures, and perspectives of our people. By embracing diversity, we believe science can achieve its fullest potential.

THE ROLE

You will be working in a multicultural and multi-disciplinary group, where junior and senior scientists collaborate, each with their expertise, to carry out a scientific activity with a shared research goal.

The “3D Chromatin Conformation and RNA Genomics ”Research Unit is coordinated byDr. Dafne Campigli Di Giammartinoandaims at understanding how non-coding elements(such as enhancers and non-coding RNAs)and their epigenetic/epitranscriptomic modifications regulate 3D genome architecture and gene expression. To address this question, we use cutting-edge chromatin conformation assays (e.g.Hi-C, Hi-ChIP etc) in conjunction with other -omics techniques (e.g. ChIPseq, RNA-seq etc.) and in combination with CRISPR-based genetic and epigenetic engineering tools in mouse stem cells as well as in human tumor stem cells.

Within the research team, your main responsibilities will be:

• Using advancedmolecular biology techniques for the manipulation of RNA, DNA and proteins in the area of3D chromatin conformation, stem cells and non-coding RNAs
• Collaborating with other lab members to implement new technologies based on CRISPR/Cas platforms and biochemical assays for the characterization of the 3D chromatin architecture
• Supervising and mentoring junior members of the team
• Recording experimental data performed in the laboratory in both paper and electronic format (e.g. benchling)
• Writing research and reviewing articles as well as assisting in generating preliminary data and figures for grant proposals

ESSENTIAL REQUIREMENTS

• PhD in Cellular/Molecular Biology, Biochemistry or similar disciplines
• Extensive experience in a molecular biology, biochemistry, genetics or cell biology laboratory
• Previous experience in producing NGS data such as ChIP-seq, RNA-seq, ATAC-seq etc
• Experience with cell culture maintenance and complementary techniques (e.g. FACS)
• Familiarity with CRISPR technologies
• Good publication record
• Strong command of spoken and written English
• Ability to work independently and collaboratively in a highly interdisciplinary environment

ADDITIONAL SKILLS

• Experience in 3D chromatin conformation assays (e.g. Hi-C, Hi-ChIP etc)
• Previous research experience in the RNA field
• Previous research experience in the stem cells field
• Ability to perform genomic and epigenomic editing in stem cells using CRISPR-(d)Cas technologies

COMPENSATION PACKAGE

• A yearly gross salary ranging between 40Kand 50K, depending on the candidate qualifications, which may include a bonus option depending on your role and contract
• Flexible working time
• Wide range of staff discounts
• Candidates from abroad or Italian citizens who have carried scientific research activity permanently abroad and meet specific requirements, may be entitled to a deduction from taxable income of up to 90% from 6 to 13 years.

Please submit your application using the online form and including:

• Your CV
• Contact info of 2-3 referees
• A 1 page Cover letter specifying your skills and motivations