Sr. Bioinformatician / Bioinformatician, Bienko Group, Erc Consolidator Grant

Human Technopole; Italia; In loco; EUR 40.000 - 48.000; Tempo pieno

Descrizione del lavoro

A leading research institute in Milan is seeking a Bioinformatician/Sr. Bioinformatician to analyze genomic data and collaborate in research projects focusing on 3D genome biology and cancer genomics. Candidates should have an M.Sc. in a relevant field and fluency in programming languages like Python or R. The role offers a competitive salary of up to €48,000, with additional benefits including flexible hours and relocation support.

Servizi

Welfare plans

Meal delivery

Work-life balance

Attractive income tax benefits

Competenze

• M.Sc. in a relevant scientific field or equivalent experience.
• Fluency in Bash, Python, or R for data analysis.
• Strong problem-solving abilities.

Mansioni

• Implement pipelines for genomic data processing.
• Analyze large sequencing datasets to study genome structures.
• Collaborate with experimentalists on research projects.

Conoscenze

Fluency in Bash

Python or R

Problem-solving skills

Strong teamwork and communication skills

Formazione

M.Sc. in Quantitative Biology, Biotechnology, Bioengineering, Genomic Sciences or equivalent

Strumenti

Hi-C

ChIP-seq

scRNA-seq

WGS/WES

Descrizione del lavoro

APPLICATION CLOSING DATE:

September 15th, 2025

Application Instructions

To apply, please forward a single document containing:

• An updated CV.
• A 1-page motivation letter in English relating your track record to the specifics of the call.
• Names and contacts of 2 referees.

About Human Technopole Foundation (HT):

HT is an interdisciplinary research institute supported by the Italian government, aiming to develop innovative strategies to promote human health and healthy aging through a multidisciplinary approach, combining genomics, computational biology, structural biology, neuroscience, and health data science. HT fosters interdisciplinary research and creates an open, collaborative environment to promote life science research nationally and internationally. It also operates National Facilities to make HT’s technologies and tools available to the scientific community.

About the lab:

The Bienko Group at HT (https://humantechnopole.it/en/research-groups/bienko-group/) focuses on understanding the principles regulating chromatin organization in mammalian cell nuclei and how 3D genome structure is affected by genomic rearrangements, such as those in human cancers.

The group invites outstanding candidates with expertise in NGS bioinformatics and interest in 3D genome biology and cancer genomics to apply for a Bioinformatician / Sr. Bioinformatician position.

Key tasks and responsibilities:

The successful candidate will work in an international, interdisciplinary team applying computational tools to study how genomic rearrangements rewire the 3D genome and influence gene expression. They will analyze large sequencing datasets generated by the lab, including various omic assays to map the 3D genome, breakome, epigenome, and transcriptome in engineered cells and patient tumor samples.

NGS assays used in the lab include:

• i) Whole-genome sequencing (WGS, short- and long-read)
• ii) Hi-C (bulk and single-cell)
• iii) GPSeq, a method developed in the lab to probe chromatin radial arrangement
• iv) Full-length RNA-seq
• v) CUT&RUN
• vi) BLISS, a method developed in the lab to map DNA double-strand breaks

Specific tasks include:

• Implementing and maintaining pipelines and software for data processing (Hi-C, WGS, RNA-seq, CUT&Tag, BLISS)
• Calling somatic alterations and structural variants by integrating WGS and Hi-C data
• Analyzing chromatin features from Hi-C data
• Peak calling from CUT&Tag data
• Gene expression analysis, transcript isoform mapping, enrichment analysis
• Integrating multi-omic datasets and comparing with public data
• Maintaining lab’s GitHub repositories
• Applying statistical methods to study genome relationships
• Proposing innovative analysis and visualization methods
• Depositing datasets in public repositories
• Collaborating with experimentalists and advising on experimental design
• Producing plots and contributing to manuscript writing

For previous work, see:

• scCircle-seq: https://doi.org/10.21203/rs.3.rs-2617401/v1
• scCUTseq: https://doi.org/10.1101/2023.11.07.566123

Job requirements:

Essential:

• M.Sc. in Quantitative Biology, Biotechnology, Bioengineering, Genomic Sciences, or equivalent. Candidates with M.Sc. in Computer Science, Mathematics, or Physics with interest in biology are welcome.
• Fluency in Bash, Python, or R.
• Problem-solving skills and motivation to tackle challenging problems.
• Strong teamwork and communication skills.
• Willingness to collaborate with experimentalists and explain computational methods clearly.
• Fluency in English, both oral and written.

Preferred:

• Experience with Hi-C, ChIP-seq, CUT&RUN/Tag, ATAC-seq, scRNA-seq, WGS/WES.

Why Human Technopole:

We seek scientific excellence, recruiting top talents through open international calls. Our environment is inclusive and collaborative, promoting interdisciplinary research with biomedical relevance. We value diversity and support training through courses, conferences, and workshops.

Main benefits:

• Welfare plans, meal delivery, work-life balance, language training, parental leave, flexible hours, remote work, relocation support, attractive income tax benefits for newcomers.

We encourage candidates from protected categories (L. 68/99) to apply.

Number of positions: 1

Salary: up to €48,000 depending on experience

Contract: Fixed-term, 3 years, CCNL Chimico Farmaceutico, employee level

Location: Milan, Italy

Funded by the EU (ERC, RADIALIS, GA n. 101088408)