Senior Scientist: Human Brain Organoids for Parkinson’s

Institute for Biomedicine – Eurac Research; Bolzano; On-site; EUR 50,000 - 52,000; Full time

Benefits offered by this job

Welfare package

International environment

Collaboration with Charité

Modern facilities at NOI Techpark

Job summary

Institute for Biomedicine – Eurac Research in Bolzano is seeking a lead scientist to drive biology workstreams for the PROTEO-NAM-PD project, developing hiPSC-derived organoids and NAMs to model GBA1-associated Parkinson’s disease.

You will coordinate experiments with Eurac Research and Charité, implement robust workflows, mentor staff, and contribute to publications and future funding while collaborating in an international environment.

Qualifications

• PhD in cell biology, neuroscience, or related discipline with 3–6 years of postdoc experience.
• Hands-on experience with advanced human cell model systems, including brain organoids or related NAMs.
• Experience in developing and applying complex in vitro models for neuroscience or translational disease research.
• Experience with phenotypic readouts such as imaging, electrophysiology, and molecular profiling.
• Strong understanding of assay reproducibility and workflow standardisation.
• Ability to work in an interdisciplinary international environment and communicate in English.

Responsibilities

• Lead development and application of hiPSC-derived midbrain organoids and NAMs for GBA1-PD.
• Design workflows to characterise disease mechanisms and responses using imaging, electrophysiology, and molecular readouts.
• Establish robust organoid generation and QC workflows with standardisation.
• Benchmark organoid NAMs against reference tissues to assess translational value.
• Collaborate with bioinformatics, proteomics and clinical partners to interpret multi-omic data.
• Support quality frameworks and contribute to publications and funding applications.
• Supervise junior staff and coordinate activities across groups.

Skills

hiPSC-derived organoids

Electrophysiology & imaging

Experimental workflow design

Team collaboration

English proficiency

Education

PhD in cell biology, neuroscience, or related field

Tools

CRISPR/Cas9 editing

High-content imaging

Proteomics & lipidomics

Job description

Institute for Biomedicine – Eurac Research in Bolzano is seeking a lead scientist to drive biology workstreams for the PROTEO-NAM-PD project, developing hiPSC-derived organoids and NAMs to model GBA1-associated Parkinson’s disease.

You will coordinate experiments with Eurac Research and Charité, implement robust workflows, mentor staff, and contribute to publications and future funding while collaborating in an international environment.