Senior position for a Medicinal Chemist

Sibylla Biotech; Milano; In loco; EUR 60.000 - 100.000; Tempo pieno

Descrizione del lavoro

Sibylla Biotech is seeking a senior medicinal chemist with a Ph.D. and over 10 years of experience in the biotech industry. The role involves leading projects in drug discovery using innovative computational methods and collaborating with a multidisciplinary team in a competitive research environment. This position offers professional growth and a competitive salary in Milan, Italy.

Servizi

Opportunities for advancement

Professional growth support

Competitive salary

Competenze

• 10+ years of experience in biotech or pharma.
• Strong knowledge of medicinal chemistry principles.
• Experience in drug discovery and development.

Mansioni

• Design and implement medicinal chemistry strategies.
• Oversee the synthesis of organic molecules at CROs.
• Make go/no-go decisions for drug candidates.

Conoscenze

Medicinal chemistry

Problem-solving

Communication skills

Project coordination

Formazione

Ph.D. in Medicinal Chemistry

Strumenti

AI-based drug design techniques

Computational chemistry

Descrizione del lavoro

Sibylla Biotech is looking for an outstanding and highly motivated senior medicinal chemist with experience in the biotech and pharmaceutical industry to join its multidisciplinary team located in Bresso (MI), Italy. Sibylla is the exclusive licensee of an innovative technology named Pharmacological Protein Inactivation by Folding Intermediate Targeting (PPI-FIT), which enables the identification of small molecules that promote the degradation of a target protein by interfering with its folding pathway. Such a new technology paves the way for the selective degradation of previously undruggable proteins. The application of our computational platform enables the characterization of previously unexplored protein conformations (folding intermediates) that can be exploited as new drug targets. The computational methods developed by Sibylla Biotech have been used to develop new pharmacological strategies for prion diseases (Spagnolli et al. 2021) and for COVID-19 (Massignan et al. 2021). This senior-level position offers the opportunity to lead and innovate within Sibylla’s medicinal chemistry team, driving the design and optimization of folding interfering small molecules. The successful candidate will play a pivotal role in advancing our pipeline from hit identification through lead optimization and candidate selection. The target role is that of principal scientist, but other roles, such as that of director, may be evaluated according to seniority. The position is to be considered in person in Milan.

Key Responsibilities

• Support medicinal chemistry activities across various therapeutic projects, encompassing stages from initial hit discovery to lead optimization and preclinical development.
• Design and implement medicinal chemistry strategies for the discovery and optimization of small molecules, integrating physics- and AI-based computational and cheminformatics tools throughout the process.
• Apply advanced medicinal chemistry principles, including structure-activity relationships (SAR), ligand- and structure-based drug design, and computational chemistry approaches.
• Oversee the synthesis of organic molecules at CROs, ensuring efficient progression of compounds through the pipeline.
• Assist in making critical go / no-go decisions for the advancement of chemical series and drug candidates.
• Stay current with emerging trends in medicinal chemistry and incorporate innovative approaches into discovery programs.
• Interface with external collaborators, contract research organizations, and academic partners.
• Partner effectively with multidisciplinary project teams, including biology, pharmacology, DMPK, safety assessment, and clinical development.
• Present scientific findings at internal meetings and external conferences.
• Contribute to developing and implementing patent strategies, safeguarding intellectual property, and preparing patent applications.
• Foster a collaborative, innovative, and results-oriented team environment.
• Contribute to the professional development of team members through coaching and training.

Qualifications

• The ideal candidate should hold a Ph.D. in Medicinal Chemistry or a closely related field with 10+ years of relevant experience in biotech or pharma.
• Work experience in the drug discovery and development industry. We discourage applications from candidates with no previous experience in the industry.
• Proven solid knowledge of medicinal chemistry.
• Experience with physics- and AI-based computer-aided drug design techniques and their application to drug discovery.
• Proven strong background in ADME assessment and multi-parameter optimization strategies.
• Proven experience in team and project coordination.
• Experience managing CRO relationships and coordinating external studies through preclinical development is a plus.
• Experience with patent strategy and intellectual property considerations in drug discovery is a plus.
• Efficient and professional communication skills in English are required.
• A high predisposition to problem-solving, enthusiasm for research, creativity, and a willingness to work in a team are also mandatory.

What We Offer

You will be part of a highly cross-disciplinary environment. Scientists in our company come from diverse scientific areas, such as theoretical physics, computer science, medicinal chemistry, and biology. You will have opportunities to break new ground. Our company is a fast-growing organization, offering excellent opportunities for advancement and promotions. You will be given responsibilities, and we will fully support your professional growth, always prioritizing your personal needs. Lastly, we also offer a competitive salary. Sibylla Biotech is an equal opportunity employer, and freedom from discrimination is a fundamental human right.

Start of the activities : As soon as possible

How to Apply

Interested applicants should submit a cover letter that includes research accomplishments and interests, with an updated CV.

Please note that only applications submitted via email will be considered.

Please send your application to all the following addresses :