Postdoctoral Position in Tumor Microenvironment

Gruppo San Donato; Milano; In loco; EUR 27.900 - 39.060; Tempo pieno

Descrizione del lavoro

San Raffaele Scientific Institute in Milan invites applications for a junior postdoctoral fellow to join the Lymphoid Stromal Cell Biology Unit of the Comprehensive Cancer Center. The project investigates reprogramming of the tumor draining lymph node in melanoma, focusing on transcriptional and phenotypic changes in stromal and immune cells.

The candidate will use cutting-edge 3D culture, single-cell RNA sequencing, and spectral flow cytometry, with access to preclinical cancer models.

Competenze

• Ph.D. in cancer biology, immunology, or equivalent research experience.
• Hands-on experience in flow cytometry, confocal imaging and pre-clinical models of cancer.
• Ability to teamwork, a solution-oriented attitude, and excellent organization skills.
• Excellent communication skills in spoken and written English are expected.

Mansioni

• Investigate transcriptional and phenotypic reprogramming of stromal and immune cells in tumor-draining lymph nodes (TDLNs).
• Utilize advanced 3D dynamic culture systems, single-cell RNA sequencing, and spectral flow cytometry.
• Collaborate with a multidisciplinary team and communicate findings effectively in English.

Conoscenze

Flow cytometry

Confocal imaging

Teamwork

Organization

English communication

Pre-clinical cancer models

Formazione

Ph.D. in cancer biology or immunology

Strumenti

3D dynamic culture systems

Single-cell RNA sequencing

Spectral flow cytometry

Preclinical cancer models

Descrizione del lavoro

A junior postdoctoral research position is available to join the Lymphoid Stromal Cell Biology Unit within the Comprehensive Cancer Center at San Raffaele Hospital.

About the project:

We are looking for an enthusiastic and motivated postdoctoral fellow to work on a project funded by the Italian Ministry of Health, focused on understanding the reprogramming of the tumor draining lymph node (TDLN) in melanoma. The successful candidate will investigate the molecular and cellular mechanisms the transcriptional and phenotypic reprogramming of stromal and immune cells in TDLNs. The successful candidate will have access to advanced 3D dynamic culture systems, single cell RNA sequencing, spectral flow cytometry and preclinical models of cancer.

Who we are looking for:

• Applicants with a Ph.D. in cancer biology, immunology or equivalent research experience;
• Hands-on experience in flow cytometry, confocal imaging and pre-clinical models of cancer;
• Ability to teamwork, a solution-oriented attitude, and excellent organization skills;
• Excellent communication skills in spoken and written English are expected.

Work details:

• Type of contract: based on experience;
• Duration: renewable up to 3 years;
• Place of work: San Raffaele Scientific Institute, Milan, Italy.

Contact details:

[e-mail]

References related to the project:

Raccosta et al., Cell Death & Disease 2023.

Lenti et al., Immunity 2022.

Farinello et al., Nature Communications 2018.

At San Raffaele Scientific Institute, a world-renowned center of excellence for clinical and scientific activities, we believe that considering diversity and promoting an open and inclusive environment is crucial to our success. We are committed to ensure that equal employment opportunities are provided and based on merit without regard to age, religion, sex, disability, medical condition, sexual orientation, cultural and social backgrounds, gender identity or expression, national or ethnic origin, or any other legally recognized status entitled to protection under applicable laws. We offer attractive conditions and rewards appropriate to an internationally competitive research organization.