Oligonucleotide Design Lead, RNA Therapeutics

Grünenthal Group; Origgio; Hybrid; EUR 90,000 - 120,000; Full time

Job summary

Grünenthal Group in Lombardia, Origgio, is seeking a senior scientist to lead the design and computational optimisation of RNA therapeutics, especially siRNA. You will integrate RNA biology with oligonucleotide chemistry to enable gene knockdown and RNA regulatory approaches, guiding target-site selection.

The role includes building scalable workflows in Python or R, collaborating with chemists and delivery scientists, and driving programs toward candidate profiling and clinical development to

Qualifications

• PhD in RNA biology, molecular biology, computational biology, or related field.
• 10+ years of industry experience, including at least 5 years in therapeutic antisense or siRNA design and optimisation.
• Strong computational skills with Python or R.

Responsibilities

• Lead design and computational optimisation of RNA therapeutics (siRNA).
• Develop computational tools and workflows to enable scalable oligonucleotide design.
• Collaborate with oligonucleotide chemists and delivery scientists to optimise sequence and chemistry.
• Lead discovery programs toward candidate profiling and clinical development.

Skills

Python

R

RNA biology

Computational biology

Cross-functional collaboration

Problem-solving

Education

PhD in RNA biology or related

Tools

Python scripting

Data analysis pipelines

Job description

Grünenthal Group in Lombardia, Origgio, is seeking a senior scientist to lead the design and computational optimisation of RNA therapeutics, especially siRNA. You will integrate RNA biology with oligonucleotide chemistry to enable gene knockdown and RNA regulatory approaches, guiding target-site selection.

The role includes building scalable workflows in Python or R, collaborating with chemists and delivery scientists, and driving programs toward candidate profiling and clinical development to