Mitochondrial Bioenergetics Researcher: Target ATPase

Italian Ministry of Education, University and Research; Italia; On-site; EUR 30,000 - 42,000; Full time

Job summary

ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - DIPARTIMENTO DI SCIENZE MEDICHE VETERINARIE seeks a researcher to identify and characterize molecules that counteract mitochondrial dysfunction by modulating F1FO-ATPase and supporting respiratory supercomplex organisation. Biochemical and bioenergetic analyses will be conducted in isolated mitochondria and cellular models.

The project aims to elucidate mechanisms of bioenergetic remodelling and develop novel mitoprotective strategies through

Qualifications

• PhD in Biochemistry, Biology or related field.
• Strong experience in mitochondrial biology and biochemical analyses.
• Experience with cellular models and bioenergetic assays.

Responsibilities

• Identify and characterize molecules modulating F1FO-ATPase.
• Perform biochemical, kinetic and bioenergetic analyses in isolated mitochondria and cellular models.
• Assess ATP synthesis/hydrolysis, mitochondrial respiration, membrane potential, ROS and calcium homeostasis.

Skills

Biochemistry

Mitochondria

Bioenergetics

Education

PhD in Biochemistry/Medicine

Tools

Mitochondrial isolation

Spectrophotometry

ROS measurement

Job description

ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - DIPARTIMENTO DI SCIENZE MEDICHE VETERINARIE seeks a researcher to identify and characterize molecules that counteract mitochondrial dysfunction by modulating F1FO-ATPase and supporting respiratory supercomplex organisation. Biochemical and bioenergetic analyses will be conducted in isolated mitochondria and cellular models.

The project aims to elucidate mechanisms of bioenergetic remodelling and develop novel mitoprotective strategies through