Identification of MAML1-induced molecular mechanisms underlying chemoresistance processes

Italian Ministry of Education, University and Research; Italia; Vor Ort; EUR 17.000 - 26.000; Vollzeit

Zusammenfassung

Sapienza Università di Roma, Dipartimento di Medicina Molecolare, cerca un ricercatore per una posizione di ricerca avanzata su TNBC e meccanismi di progressione tumorale. Il progetto esamina la suscettibilità a chemioterapici (carboplatino) e PARP inibitori e l’impatto di MAML1 sulla sopravvivenza cellulare in condizioni di stress terapeutico.

La selezione prevede qualifiche e colloquio; dettagli nel bando.

Jobbeschreibung

Organisation/Company Dipartimento di Medicina Molecolare- Sapienza università di Roma Research Field Medical sciences » Medicine Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 23 Nov 2026 - 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Triple-negative breast cancer (TNBC) is a highly aggressive tumor subtype, characterized by early onset, high metastatic capacity, and a high recurrence rate, representing a significant clinical challenge. Currently, platinum-based chemotherapy and PARP inhibitors (indicated in tumors with BRCA1/2 gene mutations) are the mainstay of systemic treatment aimed at inducing DNA damage and replicative stress. However, a significant proportion of patients show primary or acquired resistance to such treatments. In this context, the MAML1 protein emerges as a potential key regulator of tumor progression. Preliminary data indicate that MAML1 may support cell survival and proliferation under conditions of carboplatin- or olaparib-induced therapeutic stress, promoting DNA damage repair mechanisms.

• Italy

Eligibility of fellows: country/ies of residence:

• EUROPE

Eligibility of fellows: nationality/ies:

• EUROPE

Selection process

Qualifications and interview. See detail in the call