Functional Characterisation of Non-Coding RNAs and Drug Response Mechanisms in Aggressive Cancer Models

Università Degli Studi Di Firenze; Italia; On-site; EUR 38,000 - 52,000; Full time

Job summary

The University of Florence is inviting applications for a research position in biological sciences, focusing on molecular and cellular mechanisms of drug response in aggressive cancer models.

The project emphasizes the role of non-coding RNAs in treatment adaptation and resistance, involving management and characterization of human cancer cell models and functional assays for viability, proliferation, migration, invasion, apoptosis, and cell-cycle analysis using molecular and biochemical methods.

Qualifications

• Master’s degree in Biology, Medical/Biomedical Biosciences, Pharmacy or related field required.
• Candidates with Medicine degree or PhD in Biomedical Sciences or Molecular Medicine are eligible.

Responsibilities

• Investigate molecular and cellular mechanisms of drug response in aggressive cancer models.
• Manage and characterize human cancer cell models and perform functional assays assessing viability, proliferation, migration and invasion.
• Analyze cellular processes such as apoptosis and cell-cycle alterations; study gene and protein expression using molecular biology approaches.

Education

Master’s degree or LM-6/LM-9/LM-13/LM-54/LM-21 equivalent qualifications

Medicine degree or PhD in Biomedical Sciences/Molecular Medicine

Job description

Organisation/Company università degli studi di firenze Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 12 Oct 2026 - 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The research activity will focus on the investigation of the molecular and cellular mechanisms underlying drug response in aggressive cancer models, with particular emphasis on the role of non-coding RNAs in treatment adaptation and resistance.
The programme will involve the management and characterisation of human cancer cell models, functional assays addressing cell viability, proliferation, migration and invasion, and the analysis of cellular processes such as apoptosis and cell-cycle alterations. Gene and protein expression will be investigated using molecular biology and biochemical approaches.

Master’s degree or single-cycle degree required: Master’s degree in classes LM-6 (Biology), LM-9 (Medical, Veterinary, and Pharmaceutical Biotechnology), LM-13 (Pharmacy and Industrial Pharmacy), LM-54 (Chemical Sciences), or LM-21 (Biomedical Engineering), or equivalent qualifications obtained under the previous university system or abroad. Candidates holding a degree in Medicine or a PhD in Biomedical Sciences, Molecular Medicine, or an equivalent qualification are also eligible.

• Italy

Eligibility of fellows: country/ies of residence:

• EUROPE

Eligibility of fellows: nationality/ies:

• EUROPE

Selection process

In addition to their curriculum vitae, candidates may attach a brief letter outlining their background and motivations, intended to demonstrate the alignment of their scientific and professional trajectory with the activities envisaged by the research program.