Principal Project Scientist

Sudha Gopalakrishnan Brain Centre (SGBC); Chennai District; On-site; INR 3,000,000 - 6,000,000; Full time

Job summary

The Centre for 3D Cancer Omics at IIT Madras seeks an experienced Senior Cancer Biologist to lead a multidisciplinary team focused on histological and molecular profiling of solid tumours. You will drive 3D tissue mapping, liquid biopsy, and multiomics, guiding wet-lab and computational workflows from tissue processing to data integration.

Applicants should have a Ph.D. in a related field and 7+ years of post-doctoral or industry experience, with strong leadership and expertise in digital

Qualifications

• Ph.D. in a relevant field and a strong publication record.
• 7+ years post-Ph.D. in solid tumor oncology or related field.
• Proven leadership experience and ability to mentor cross-functional teams.

Responsibilities

• Direct and mentor a cross-functional team in 3D digital histopathology, spatial transcriptomics and multiomics with computational analysis
• Architect experimental pipelines for 3D tissue mapping and liquid biopsy assays, integrating molecular data with histopathological findings
• Manage facility operations, oversee high-throughput data generation and drive methodological innovation
• Handle resource allocation and draft research proposals
• Collaborate across clinical, wet-lab and computational teams to translate research into precision oncology outcomes

Skills

Digital histopathology

Multiomics

Team leadership

Computational analysis

Tissue processing

Education

Ph.D. in Cancer Biology, Molecular Genetics, Genomics or related

Tools

NGS workflows

Spatial transcriptomics platforms

Bioinformatics tools (open-source)

Digital histopathology platforms

Job description

The Centre for 3D Cancer Omics at IIT Madras is a Focused Research Organization dedicated to advancing multidisciplinary digital tissue mapping and high-resolution histopathology in oncology. Operating at the intersection of clinical research, tissue imaging, molecular biology and computational science, we decode complex tumor microenvironments at scale. Our infrastructure integrates 3D histology, multiomics, spatial biology and liquid biopsy pipelines, with a focus on the unique genomic and clinical landscapes of Indian cohorts.

Workplace: On-site

Type: Full-time

Role Summary

We are looking for an experienced Senior Cancer Biologist to lead a multidisciplinary team working on histological and molecular profiling of solid tumours. You will integrate high-resolution 3D histology, liquid biopsy and multiomics, and direct wet-lab and computational workflows from tissue processing to multi-omic data integration.

Key Responsibilities

• Direct and mentor a cross-functional team in 3D digital histopathology, spatial transcriptomics and multiomics with computational analysis
• Architect experimental pipelines for 3D tissue mapping and liquid biopsy assays, integrating molecular data with histopathological findings
• Manage facility operations, oversee high-throughput data generation and drive methodological innovation
• Handle resource allocation and draft research proposals
• Collaborate across clinical, wet-lab and computational teams to translate research into precision oncology outcomes

Required Qualifications

• Ph.D. in Cancer Biology, Molecular Genetics, Genomics or a related discipline from a reputed institute
• 7+ years of post-doctoral or industry experience in solid tumor oncology (minimum 5 years with a proven track record of team leadership)
• Expertise in digital histopathology and multiomics
• Experience establishing and optimizing digital histopathology pipelines, NGS workflows and molecular probing methods beyond standard commercial kits
• Extensive experience with liquid biopsy protocols, spatial transcriptomics platforms and histopathology environments
• Familiarity with bioinformatics and open-source tools for cancer image analysis and multiomics data analysis

Preferred

• Experience establishing or managing a molecular oncology or histopathology core facility
• Deep familiarity with solid tumor pathology, NGS, biomarker analysis and validation, and spatial biology platforms