Senior Scientist (Chemistry)

AstraZeneca; Dublin; On-site; EUR 70,000 - 110,000; Full time

Job summary

AstraZeneca plc in Dublin is seeking a Senior Scientist (Chemistry) to contribute to transfer, maintain and optimise supply for AstraZeneca products. You will drive process improvements using traditional and cutting-edge technologies, and provide hands-on experimentation and modelling support at our Dublin site.

You will contribute to CMC sections of regulatory submissions and respond to queries over the product lifecycle, with a focus on scale-up/down, process robustness, and cGMP compliance.

Qualifications

• BSc/PhD in a relevant discipline with pharma R&D or manufacturing experience.
• Expert understanding of practical synthetic organic chemistry in lab and production.
• Experience with Tech Transfer of Drug Substance processes.
• Experience scaling up and scaling down processes in pharma.
• Understanding of drug development from discovery to launch.
• Knowledge of SHE and cGMP principles and management.
• Strong communication and influence across interfaces and teams.
• Problem solving with deep technical skills and data-driven approach.
• Proficiency in statistics to understand data.

Responsibilities

• Support transfer, maintain and optimise supply for one or more AstraZeneca products.
• Identify, develop and implement process improvements using existing and cutting-edge technologies.
• Provide expert input through laboratory experiments, in-silico modelling and direct manufacturing support at the Dublin site.
• Contribute to CMC components of regulatory submissions and responses over the product lifecycle.

Skills

Organic synthesis

Tech Transfer

Scale-up/Scale-down

CMC regulatory

GMP/cGMP

Statistical analysis

Education

BSc/PhD in chemistry

Job description

Senior Scientist (Chemistry)

Location: Dublin

Competitive Salary and Benefits

Accountabilities

As a Senior Scientist, you will be responsible for supporting the technical contribution to transfer, maintain and optimise supply for one or more AstraZeneca commercial products. You will identify, develop and implement process improvements for both launch and commercial products through the use of existing and cutting-edge technologies. You will also provide expert technical input through laboratory experimentation, in-silico modelling and direct manufacturing support at our internal AZ API manufacturing site in Dublin. Your role will also involve contribution to the CMC components of regulatory submissions and preparation of successful query responses over the commercial life of a product.

Essential Skills/Experience

• BSc/PhD level education in a relevant discipline and experience working within a Research & Development or Manufacturing environment, within the pharmaceutical industry.
• Technical expertise and understanding of practical synthetic organic chemistry spanning across both lab and manufacture.
• Experience in the Tech Transfer of pharmaceutical small molecule Drug Substance processes
• Background in dealing with the challenges of both the scale up and scale down of processes
• A good understanding of the overall drug development process from discovery through to launch.
• A thorough understanding of the principles and management of SHE and cGMP.
• Excellent communication and strategic influencing skills across interfaces of discipline, culture, and expertise both internally and externally.
• Proven problem solver with in depth technical skills.
• Proficiency in the use of statistics to understand data.
• Ability to think and operate across functional boundaries, challenge the status quo and seek opportunities for business improvement.

Desirable Skills/Experience

• Experience of delivering CMC content or contributions to regulatory filings throughout the life cycle of process development, in the pharmaceutical industry.
• Experience working within a Research & Development and Manufacturing environment in the pharmaceutical industry
• Experience of technical supervision and leading small teams of people or scientific projects.
• Experience of late stage development or commercial supply with a background in a process chemistry skill group
• Experience of working across skillsets (e.g. with chemists, analysts and physical properties experts).

Why AstraZeneca?

At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients, and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth, and development!

Find out more on Social Media

• LinkedIn https://www.linkedin.com/company/1603/
• Facebook https://www.facebook.com/astrazenecacareers/
• Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
• About Operations https://www.youtube.com/watch?v=gak5Ham8oUw

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We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Date Posted 10-Nov-2026

Closing Date 21-Nov-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.