Senior Scientist (Chemistry)

AstraZeneca; Blanchardstown; On-site; EUR 70,000 - 90,000; Full time

Job summary

AstraZeneca plc in Dublin is seeking a Senior Scientist (Chemistry) to support the technical contribution to transfer, maintain and optimise supply for one or more AstraZeneca commercial products. You will identify, develop and implement process improvements using existing and cutting-edge technologies, and provide expert input through laboratory experimentation and in-silico modelling.

The role involves direct manufacturing support at the AZ API site in Dublin and contributing to CMC sections

Qualifications

• PhD or MSc in a relevant discipline with pharma R&D or manufacturing experience.
• Expertise in practical synthetic organic chemistry from lab to manufacture.
• Experience in Tech Transfer of small molecule drug substance processes.
• Experience handling scale-up and scale-down of processes.
• Strong understanding of drug development from discovery to launch.
• Solid knowledge of SHE and cGMP principles.
• Excellent communication and strategic influencing skills.
• Proven problem solver with deep technical skills.
• Proficiency in statistics to interpret data.

Responsibilities

• Support the technical contribution to transfer, maintain and optimise supply for AstraZeneca commercial products.
• Identify, develop and implement process improvements using existing and cutting-edge technologies.
• Provide expert technical input through laboratory experiments, in-silico modelling, and direct manufacturing support at our internal AZ API manufacturing site in Dublin.
• Contribute to the CMC components of regulatory submissions and preparation of successful query responses over the commercial life of a product.

Skills

Synthetic organic chemistry

Tech Transfer

Scale-up / scale-down

Regulatory input (CMC)

Statistics

Cross-functional collaboration

Problem solving

Communication

Data interpretation

Education

BSc/PhD in a relevant discipline

Job description

Senior Scientist (Chemistry)

Location: Dublin

Competitive Salary and Benefits

Accountabilities:

As a Senior Scientist, you willbe responsible forsupporting the technical contribution totransfer,maintainand optimise supply for one or more AstraZeneca commercial products. You willidentify,developand implement process improvements forboth launch andcommercial productsthrough the use ofexisting andcutting-edgetechnologies. You will also provide expert technical inputthroughlaboratory experimentation, in-silicomodellingand direct manufacturing supportat ourinternal AZ API manufacturing sitein Dublin. Your role will also involve contribution to the CMC components of regulatory submissions and preparation of successful query responses over the commercial life of a product.

Essential Skills/Experience:

• BSc/PhD level education in a relevant discipline and experience working within a Research & Development or Manufacturing environment, within the pharmaceutical industry.
• Technicalexpertiseand understanding of practical synthetic organic chemistryspanning across both lab and manufacture.
• Experience in the Tech Transfer ofpharmaceutical small molecule Drug Substanceprocesses.
• Background in dealing with the challenges of both the scale up and scale down of processes.
• A good understanding of the overall drug development process from discovery through to launch.
• A thorough understanding of the principles and management of SHE and cGMP.
• Excellent communication and strategic influencing skills across interfaces of discipline, culture, andexpertiseboth internally and externally.
• Proven problem solverwith indepth technical skills.
• Proficiencyin the use of statistics to understand data.
• Ability to think andoperateacross functional boundaries, challenge thestatus quoand seek opportunities for business improvement.

Desirable Skills/Experience:

• Experience of delivering CMC content or contributions to regulatory filings throughout the life cycle of process development, in the pharmaceutical industry.
• Experience working within a Research & Development and Manufacturing environmentinthe pharmaceutical industry
• Experience of technical supervision and leading small teams of people or scientific projects.
• Experience of late stagedevelopment or commercial supply with a background in aprocess chemistry skill group
• Experience of working across skillsets (e.g.with chemists,analystsand physical properties experts).

Why AstraZeneca?

At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients, and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth, and development!

Find out more on Social Media:

• LinkedIn https://www.linkedin.com/company/1603/
• Facebook https://www.facebook.com/astrazenecacareers/
• Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
• About Operations https://www.youtube.com/watch?v=gak5Ham8oUw

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Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.