Downstream Technical Ops Mgr

MSD

Dunboyne

Hybrid

EUR 110,000 - 140,000

Full time

5 days ago

Be an early applicant

Get more replies from employers

Send a job-specific resume in minutes.

Job summary

MSD in Dunboyne, Co. Meath, invites applications for a Downstream Technical Operations Manager.

You will oversee a team of engineers and scientists across chromatography, filtration and formulation, owning end-to-end technical accountability for a complex biologics programme and manufacturing support. Reporting to the Associate Director, you will drive technology transfer, process improvement, risk management and strategic execution, balancing hands-on technical leadership with people management

Qualifications

Bachelor's Degree (Level 8) in Engineering, Science or equivalent.
Six years' experience in a biologics drug substance environment.
Technical expertise in upstream and/or downstream purification unit operations.

Responsibilities

Lead and manage a team of engineers and scientists within the MS&T department.
Lead technology transfer activities for clinical and commercial projects.
Develop strategies for technology transfer and process activities in line with regulatory standards.
Act as a process subject matter expert for investigations and guidance.

Skills

People Leadership

Technology Transfer

Strategic Development

Risk Management

Project Leadership

Coaching

Process Improvement

QMS

Regulatory Compliance

Team Leadership

Technology Transfer

Education

Bachelor's degree (Level 8)

Tools

PAS

MES

Job description

Job Description

An outstanding opportunity for a highly skilled technical leader to join the downstream technical operations function at our state-of-the-art biologics manufacturing site in Dunboyne, Co. Meath.

The Downstream Technical Operations Manager holds end-to-end technical accountability for a complex biologics programme, leading a dedicated team across the full range of downstream unit operations, including chromatography, filtration, and formulation, with accountability for manufacturing support.

This role is accountable for ensuring that a team of scientists and engineers has the appropriate scientific depth, process knowledge, and problem-solving capability to meet the evolving demands of a diverse and growing biologics pipeline. The manager will drive technical readiness, manufacturing robustness, and continuous improvement across the product lifecycle.

Reporting to the Downstream Technical Operations Associate Director, this role requires a technical leader who can balance hands-on technical engagement with effective people leadership, cross-functional collaboration, and strategic programme delivery.

Our facility in Dunboyne joined the global manufacturing network in September 2020. The Dunboyne site is a biologics drug substance single-use commercialisation facility, playing a significant role in helping to commercialise key medicines. The innovation and collaboration between research and manufacturing teams help accelerate the time it takes to bring medicines to market for the benefit of patients around the world.

Key Responsibilities

Lead and Manage Teams Oversee and mentor a team of engineers and scientists within the MS&T department, fostering a collaborative and high-performance culture.
Technology Transfer Leadership Responsible for leading key technology transfer activities in support of a diverse range of clinical and commercial new product introduction projects.
Strategic Development Develop strategies for, and support the execution of, technology transfer and process activities in line with industry and regulatory standards.
Subject Matter Expert Act as a process Subject Matter Expert in support of process investigations and provide guidance to team members.
Risk Management Use risk management techniques to assess strategies, prioritise activities, and support initiatives.
Project Leadership Lead significant business-critical projects on-site associated with new product introduction and site capability build.
Coaching and Development Support the coaching and professional development of other members of the technical operations team, ensuring continuous learning and skill enhancement.
Ongoing Optimisation Drive the ongoing optimisation of process equipment and the development of future breakthrough business solutions.

Your Profile

Minimum of a Bachelor's Level 8 degree in a technical field (e.g., Engineering, Science, or equivalent), with experience in the biotechnology or pharmaceutical industry.
Minimum of six years' experience in a biologics drug substance environment.
Technical expertise in biological drug substance upstream and/or downstream purification unit operations required.
Experience in technology transfer for clinical or commercial biologics is strongly desired.
Experience with automated systems (PAS, MES) is highly desired.
Process validation and cleaning validation experience is desired.
Proven ability to manage multiple priorities and know when to elevate for resolution.
Flexible and self-motivated, with a proven ability to work cross-functionally to deliver technical solutions to issues.

Ability to travel internationally, as the role has a minimal travel requirement of approximately <5% per annum.

We keep patients at the heart of everything we do and strive to find solutions and treatments for some of the world’s most challenging healthcare needs. If you are ready to invent solutions that address unmet healthcare needs, help shape the future of healthcare, and inspire your team to reach their full potential while pushing the boundaries of science and technology.

Required Skills