Associate Director, Downstream Technical Operations Lead

MSD; Dunboyne; Hybrid; EUR 120,000 - 180,000; Full time

Job summary

MSD in Dunboyne is seeking an Downstream Technical Operations Lead who will hold end-to-end technical, manufacturing, and people accountability for a complex biologics program. You will lead a high-performing team delivering day-to-day support across chromatography, filtration, and formulation.

Reporting to the Downstream Technical Operations Director, you will shape technical strategy, enable robust GMP-compliant production, and mentor scientists and engineers while collaborating with global

Qualifications

• Degree B.S., M.S., or Ph.D. in a relevant Engineering or Scientific discipline.
• 8-10 years of experience in biopharmaceutical manufacturing and/or development, with a proven track record in scientific and technical leadership roles.

Responsibilities

• Maintain end-to-end technical ownership of the assigned biologics program, guiding activities from technology transfer and PPQ execution through to commercial lifecycle management.
• Act as a core member of the Downstream technical leadership team, helping to shape the site's overall technical strategy and execution standards.
• Enable robust, compliant, and reliable production by providing visible, floor-based technical support to resolve real-time manufacturing issues.
• Set clear priorities, expectations, and decision-making frameworks to ensure rapid deviation investigations, root-cause analyses, and change implementation.
• Mentor team members through complex problem-solving, stretch assignments, and subteam leadership opportunities to strengthen site succession plans.

Skills

Leadership

GMP Compliance

Chromatography

Process Engineering

Technology Transfer

Regulatory Filings

CAPA Management

Project Management

Education

Bachelor's/Master/PhD in Engineering or Science

Tools

CMMS (Computerized Maintenance Management Systems)

Automation

Job description

Job Description

Join our state-of-the- Dunboyne as the Downstream Technical Operations Lead.

In this pivotal role, you will hold end-to-end technical, manufacturing, and people accountability for a complex, growing biologics program. Reporting directly to the Downstream Technical Operations Director as part of the MSAT function, you will lead a high-performing team of scientists and engineers delivering day-to-day manufacturing support across all downstream unit operations - including chromatography, filtration, and formulation.

What You Will Do

Technical Program Ownership

• Maintain end-to-end technical ownership of the assigned biologics program, guiding activities from technology transfer and PPQ execution through to commercial lifecycle management.
• Act as a core member of the Downstream technical leadership team, helping to shape the site's overall technical strategy and execution standards.

Manufacturing Support & Operational Excellence

• Enable robust, compliant, and reliable production by providing visible, floor-based technical support to resolve real-time manufacturing issues.
• Set clear priorities, expectations, and decision-making frameworks to ensure rapid deviation investigations, root-ca_cause analyses, and change implementation.
• Proactively identify, assess, and resolve manufacturing risks, establishing strong escalation practices and transparent communication with site and global stakeholders.

People Leadership & Talent Development

• Lead, coach, and develop a team of downstream scientists, engineers, SMEs, and subteam leads, ensuring clear accountabilities, capacity management, and strong engagement.
• Foster a culture of continuous learning, scientific rigor, engineering excellence, psychological safety, and lean-driven improvement.
• Mentor team members through complex problem-solving, stretch assignments, and subteam leadership opportunities to strengthen site succession plans.

Cross-Functional Collaboration

• Collaborate closely with Downstream Receiving Unit lead, Integrated Process Teams, Commercialisation partners, and the Global Biologics Organisation to align technical priorities, share best practice, and accelerate the successful delivery of a complex and evolving pipeline.
• Partner closely at the interface between Development, Quality, Engineering, Automation, Supply Chain, and global technical partners to drive strategic program delivery.

What Skills You Will Need

Education & Professional Experience

• Degree B.S., M.S., or Ph.D. in a relevant Engineering or Scientific discipline.
• Experience A minimum of 8-10 years of experience in biopharmaceutical manufacturing and/or development, with a proven track record in scientific and technical leadership roles.

Technical & Operational Expertise

• Downstream Processes Deep technical expertise in biologics molecules, chromatography, filtration, formulation, process equipment, and automation.
• Product Lifecycle Proven experience in biologics drug substance development, downstream technical operations, technology transfer, PPQ, and new product introduction.
• GMP Compliance Strong operational experience in a highly regulated GMP environment, including floor-based support, regulatory filings, investigations, quality notifications, CAPA management, and process monitoring.
• Business Acumen Solid understanding of product lifecycle management, financial stewardship, and the ability to manage resource allocation across multiple complex programs simultaneously.

Leadership & Influence

• Leading Through Others Proven ability to build, scale, and lead high-performing technical teams, setting clear priorities and coaching technical decision-making.
• Stakeholder Management Excellent communication and presentation capabilities, with a demonstrated ability to influence and collaborate across all levels of a global network.
• Agility & Drive A strong sense of urgency, resilience, and change agility, combined with an engaging, motivational leadership style.

Why Join Us?

• Work in a cutting-edge, state-of-the- art biologics facility in Dunboyne.
• Lead a diverse, growing pipeline of biologics programs.
• Drive technical excellence within a highly collaborative, cross-functional global network.

Required Skills

Business Acumen, Business Acumen, Business Management, Change Adoption, Chromatography, Computerized Maintenance Management Systems (CMMS), Cross-Cultural Awareness, Deviation Investigations, Financial Management, GMP Compliance, GMP Environments, Maintenance Supervision, Manufacturing Quality Control, Manufacturing Support, People Leadership, Pharmaceutical Development, Process Engineering, Process Improvements, Product Lifecycle, Regulatory Compliance, Regulatory Inspections, Resource Allocation, Single-Use Systems (SUS), Sterile Manufacturing, Strategic Thinking {+ 1 more}

Employee Status

Regular

Flexible Work Arrangements

Hybrid

Job Posting End Date

08/20/2026

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