Associate Director, Upstream Technical Operations Lead

MSD Ireland; Dunboyne; Hybrid; EUR 140,000 - 190,000; Full time

Benefits offered by this job

Hybrid work arrangement

Job summary

MSD Ireland in Ireland is seeking an Upstream Technical Operations Lead to hold end-to-end technical, manufacturing, and people accountability for a complex biologics program. You will lead a high-performing team across media preparation, culture, bioreactor operations, harvest, and monitoring.

You will report to the Upstream Technical Operations Director within MSAT, shaping technical strategy and standards while ensuring GMP compliance and successful tech transfer and PPQ milestones.

Qualifications

• Degree in engineering or science; PhD preferred.
• 8–10 years in biopharmaceutical manufacturing or development.
• Proven leadership in technical teams.
• Experience with PPQ, tech transfer, GMP.

Responsibilities

• Own end-to-end technical ownership of the biologics program from technology transfer through to lifecycle management.
• Provide floor-based technical support to resolve real-time manufacturing issues and enable robust production.
• Lead, coach and develop upstream scientists, engineers and subteams with clear accountabilities.
• Collaborate with downstream, quality, engineering, and global partners to align priorities and deliver complex programs.

Skills

Biopharma manufacturing

Technical leadership

GMP compliance

Process engineering

Stakeholder management

Education

BS/MS/PhD in engineering

Job description

Job Description

Join our state-of-the-art biologics manufacturing facility in Dunboyne as the Upstream Technical Operations Lead.

In this pivotal role, you will hold end-to-end technical, manufacturing, and people accountability for a complex, growing biologics program. Reporting directly to the Upstream Technical Operations Director as part of the MSAT function, you will lead a high-performing team of scientists and engineers delivering day-to-day manufacturing support across the entire upstream process—from media preparation and cell culture to bioreactor operations, harvest, and process monitoring.

What You Will Do

Technical Program Ownership

• Maintain end-to-end technical ownership of the assigned biologics program, guiding activities from technology transfer and PPQ execution through to commercial lifecycle management.
• Act as a core member of the Upstream technical leadership team, helping to shape the site's overall technical strategy and execution standards.

Manufacturing Support & Operational Excellence

• Enable robust, compliant, and reliable production by providing visible, floor-based technical support to resolve real-time manufacturing issues.
• Set clear priorities, expectations, and decision-making frameworks to ensure rapid deviation investigations, root-cause analyses, and change implementation.
• Proactively identify, assess, and resolve manufacturing risks, establishing strong escalation practices and transparent communication with site and global stakeholders.

People Leadership & Talent Development

• Lead, coach, and develop a team of upstream scientists, engineers, SMEs, and subteam leads, ensuring clear accountabilities, capacity management, and strong engagement.
• Foster a culture of continuous learning, scientific rigor, engineering excellence, psychological safety, and lean-driven improvement.
• Mentor team members through complex problem-solving, stretch assignments, and subteam leadership opportunities to strengthen site succession plans.

Cross-Functional Collaboration

• Collaborate closely with Downstream Receiving Unit lead, Integrated Process Teams, Commercialisation partners, and the Global Biologics Organisation to align technical priorities, share best practice, and accelerate the successful delivery of a complex and evolving pipeline.
• Partner closely at the interface between Development, Quality, Engineering, Automation, Supply Chain, and global technical partners to drive strategic program delivery.

What Skills You Will Need

Education & Professional Experience

• Degree: B.S., M.S., or Ph.D. in a relevant Engineering or Scientific discipline.
• Experience: A minimum of 8–10 years of experience in biopharmaceutical manufacturing and/or development, with a proven track record in scientific and technical leadership roles.

Technical & Operational Expertise

• Upstream Processes: Deep technical expertise in biologics molecules, cell culture, seed train, bioreactor operations, media/feed strategies, harvest, process equipment, and automation.
• Product Lifecycle: Proven experience in biologics drug substance development, technology transfer, PPQ, and new product introduction.
• GMP Compliance: Strong operational experience in a highly regulated GMP environment, including regulatory filings, investigations, quality notifications, CAPA management, and audit readiness.
• Business Acumen: Solid understanding of product lifecycle management, financial stewardship, and the ability to manage resource allocation across multiple complex programs.

Leadership & Influence

• Leading Through Others: Proven ability to build, scale, and lead high-performing technical teams, setting clear priorities and coaching technical decision‑making.
• Stakeholder Management: Excellent communication and presentation capabilities, with a demonstrated ability to influence and collaborate across all levels of a global network.
• Agility & Drive: A strong sense of urgency, resilience, and change agility, combined with an engaging, motivational leadership style.

Why Join Us?

• Work in a cutting‑edge, state‑of‑the‑art biologics facility in Dunboyne.
• Lead a diverse, growing pipeline of biologics programs.
• Drive technical excellence within a highly collaborative, cross‑functional global network.

Required Skills

Business Acumen, Business Acumen, Business Management, Cell Cultures, Change Adoption, Computerized Maintenance Management Systems (CMMS), Cross-Cultural Awareness, Financial Management, GMP Compliance, GMP Environments, Maintenance Supervision, Mammalian Cell Culture, Manufacturing Quality Control, Manufacturing Support, People Leadership, Pharmaceutical Development, Process Engineering, Process Improvements, Product Lifecycle, Regulatory Compliance, Regulatory Inspections, Resource Allocation, Single-Use Systems (SUS), Sterile Manufacturing, Strategic Thinking {+ 1 more}

Employee Status

Regular

Flexible Work Arrangements

Hybrid

Job Posting End Date

08/20/2026

• A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R410698