Biopharma Process Engineer — PAT, Modeling & Digitalization

Metric Bio; Dublin; On-site; EUR 60,000 - 95,000; Full time

Job summary

Metric Bio is seeking an experienced Process Development/ MSAT engineer to advance biopharmaceutical process development, integrating PAT, QbD, and DoE methodologies. The role emphasizes scale-up and tech transfer for upstream and downstream unit operations, with emphasis on data-driven workflow improvements and GLP/GMP compliance.

The successful candidate will contribute to cross-functional projects, develop digital workflows, and mentor junior staff while delivering technical reports and

Qualifications

• Minimum of 1–2 years of industry experience in Process Development Engineering or Manufacturing Sciences & Technology (MSAT) with MSc, or 3+ years with a bachelor.
• Strong understanding of chemical engineering fundamentals across upstream and/or downstream bioprocessing.
• Knowledge of QbD, DoE, and process characterization methodologies.
• Experience with scale-up/scale-down models and technology transfer for upstream and/or downstream processes.
• Experience using statistical analysis software such as JMP, Minitab, R, Python, or MATLAB.

Responsibilities

• Work within a multidisciplinary research team to support planning, organization, and execution of pharmaceutical process development R&D programs.
• Design and establish scale-down laboratory models for unit operations to understand and optimize manufacturing-scale processes.
• Develop and enhance digital workflows for process monitoring, data acquisition, chemometric analysis, and data integration.
• Lead the development and implementation of new technologies including PAT for upstream and downstream bioprocess unit operations.
• Prepare and review technical reports, presentations, and project documentation; present findings to clients as required.
• Apply engineering principles and computations to solve complex technical challenges.
• Ensure GLP-compliant laboratory activities and support GMP/regulatory requirements.
• Collaborate with cross-functional teams to maintain operations and address facility or equipment issues.
• Coach and train junior team members where appropriate.

Skills

Chemical engineering fundamentals

Quality by Design

Design of Experiments

Process characterization

Statistical analysis

Project management

Technical communication

Education

MSc in Engineering/related field

Bachelor's degree in Engineering/Science

Tools

CFD

MATLAB

Python

MVDA

Dynochem

gPROMS

Aspen Plus

JMP

Minitab

R

Job description

Metric Bio is seeking an experienced Process Development/ MSAT engineer to advance biopharmaceutical process development, integrating PAT, QbD, and DoE methodologies. The role emphasizes scale-up and tech transfer for upstream and downstream unit operations, with emphasis on data-driven workflow improvements and GLP/GMP compliance.

The successful candidate will contribute to cross-functional projects, develop digital workflows, and mentor junior staff while delivering technical reports and