Senior Scientist / Research Scientist (In-vitro / Cellular Pharmacology), London

Isomorphic Labs; London; Hybrid; GBP 125,000 - 150,000; Full time

Job summary

A leading biotech company in London seeks an experienced individual for an in-vitro pharmacology role. This position involves designing biological screening cascades and collaborating on innovative drug discovery projects. The ideal candidate has a strong background in biology, extensive pharmacology expertise, and experience with CROs. The company offers a hybrid working model and values diverse perspectives to drive groundbreaking innovations.

Qualifications

• Extensive experience in designing biological screening cascades.
• Deep knowledge of experimental in-vitro pharmacology techniques.
• Experience working with CROs on biological data.

Responsibilities

• Design biological screening cascades for drug design programs.
• Work with CROs to deliver biological data.
• Collaborate with Drug Design and Technology teams.

Skills

Biophysical, biochemical and/or cell-based functional assays

Effective communication

Dynamic and agile working style

Education

BSc, MSc or PhD in a relevant field of biology

Job description

Overview

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming, enabled by the power of machine learning, to accelerate drug discovery and curb or cure diseases.

Join an interdisciplinary team driving groundbreaking innovation and contribute to achieving our ambitious goals within an inspiring and collaborative culture. The world we want tomorrow starts with the culture at IsoLabs and with you.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI\'s powerful capabilities, we model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world\'s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that operate across multiple therapeutic areas and drug modalities. We continually innovate on model architecture and develop cutting-edge capabilities to advance rational drug design.

Every day, with each new breakthrough, we move closer to the promise of digital biology and our mission to one day solve all disease with the help of AI.

Your impact

Isomorphic Labs is seeking exceptional individuals to join an impactful in-vitro pharmacology sub team within our translational science team, working in multidisciplinary ML-based drug discovery medical research.

These roles are ideal for experienced in-vitro pharmacologists with significant working knowledge of biophysical, biochemical and/or cell-based functional assays who have extensive experience providing quantitative in-vitro pharmacology expertise within drug discovery projects.

This is an exciting opportunity to work closely with world‑leading AI, ML and drug discovery experts to test biological hypotheses, build a deep mechanistic understanding of drug target interactions, and drive our projects forward. You will help define the screening cascades for our drug design projects, advancing our oncology, immunology and partnership portfolios from early drug discovery through to candidate selection and clinical phase work.

You will have experience across drug discovery projects and the ability to think originally and critically, knowing when to apply innovative ideas, and maintaining a beginner\'s mindset.

What you will do

• Design efficient and comprehensive biological screening cascades for a variety of internal and partnered drug design programs.
• Work with CROs to design decision-making experiments, and deliver high-quality biological data to inform the path to the clinic.
• Work cross-functionally with our Drug Design and Technology teams.

Skills and qualifications

Essential:

• BSc, MSc or PhD in a relevant field of biology.
• Extensive experience in the design and implementation of biological screening cascades applied to drug design projects from hit identification to Candidate Selection phases.
• Deep knowledge of experimental in-vitro pharmacology techniques including biophysical, biochemical and/or cellular assays.
• Experience working with CROs in acquiring and interpreting high quality biological data in a timely manner.
• Dynamic, agile, and flexible individual who can work across many projects, therapeutic areas, and multi-disciplinary teams.
• Effective communication across a broad interdisciplinary team, working with key stakeholders with different skills and backgrounds.

Nice to have:

• Experience in project leadership or leading biology within drug discovery programs, ideally from inception to clinical candidate delivery.
• Worked with Data Science groups in setting up systems for ingestion of biological data.
• Track record of contributing to drug design projects which have then delivered Clinical Candidates.
• Working knowledge of designing and implementing assays and screening cascades for alternative modalities or alternative chemistries e.g peptides or molecular glues.
• General knowledge of machine learning modelling applied to biological systems and drug discovery.
• Experience of target identification, validation and selection approaches.

Culture and values

We are guided by our shared values. It\'s not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

Thoughtful in Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave in Iso is about fearlessness, initiative and integrity. The scale of the challenge demands nothing less.

Determined in Iso is the way we pursue our goal. It\'s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won\'t wait, so neither should we.

Together in Iso is about connection, collaboration across fields and catalytic relationships. It\'s knowing that transformation is a group project, and remembering that what we\'re doing will have a real impact on real people everywhere.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We\'re building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital or domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please let us know.

Hybrid working

We follow a hybrid model and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on team). If you have additional needs that would prevent this, we\'d be happy to discuss them if you are selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy.

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