Senior Scientist, Molecular Biology — High-Throughput Vector Design

Zealand Pharma; Cambridge; On-site; GBP 92,000 - 126,000; Full time

Job summary

Zealand Pharma A/S seeks a Scientist or Senior Scientist in Molecular Biology to drive high-throughput vector design and cloning, enabling discovery across display technologies and structural biology. The role centers on building foundational molecular biology capabilities at our Cambridge, MA center, with emphasis on vector design, cloning, and cell line engineering.

You will generate constructs for challenging targets (GPCRs, multi-pass proteins), use CRISPR-Cas9 and lentiviral methods, and

Qualifications

• PhD in Molecular Biology, Cell Biology, Biochemistry or related field preferred.
• 2+ years post-degree in vector design, cloning, cell line engineering (Scientist); 4+ years (Senior Scientist).
• Expertise in high-throughput vector design and cloning workflows (Golden Gate, Gibson).
• Experience with GPCRs and multi-pass TM proteins and related targets.

Responsibilities

• Design and construct high-throughput expression vectors for recombinant protein production.
• Generate constructs and reagents for challenging targets (GPCRs, receptor-Fc fusions, biotinylated ligands).
• Engineer mammalian host cell lines using modern genome editing approaches (CRISPR-Cas9, lentiviral transduction).
• Support target bait proteins and cell lines for display, interaction studies, and structural biology workflows.

Skills

Vector design

Molecular cloning

Cell line engineering

High-throughput workflows

CRISPR-Cas9 genome editing

Lentiviral transduction

Education

PhD in Molecular Biology or related field

BS/MS with significant industry experience

Tools

Golden Gate

Gibson assembly

CRISPR-Cas9

Lentiviral transduction

Job description

Zealand Pharma A/S seeks a Scientist or Senior Scientist in Molecular Biology to drive high-throughput vector design and cloning, enabling discovery across display technologies and structural biology. The role centers on building foundational molecular biology capabilities at our Cambridge, MA center, with emphasis on vector design, cloning, and cell line engineering.

You will generate constructs for challenging targets (GPCRs, multi-pass proteins), use CRISPR-Cas9 and lentiviral methods, and