Senior Scientist – Immunology / Translational Research

VRS Recruitment; Slough; On-site; GBP 55,000 - 75,000; Full time

Job summary

VRS Recruitment is seeking a Senior Scientist – Immunology/Translational Research to join its Immunology Research team, within the Resolution of Inflammation focus area. The role involves designing experiments to understand target biology and mechanisms of action of novel therapeutics.

The candidate will work with multidisciplinary teams, develop translational in vitro and ex vivo assays, and analyse complex datasets including RNA-seq, scRNA-seq and proteomics.

Qualifications

• PhD in immunology or related field with postdoc experience.
• Experience with translational immunology projects and disease models.
• Hands-on experience with primary human cells and ex vivo assays.

Responsibilities

• Design and run translational in vitro and ex vivo assays.
• Work with primary human cells to develop disease models.
• Utilise immunology techniques including flow cytometry, qPCR and RNA-based analyses.
• Analyse large datasets from RNA-seq, spatial transcriptomics and proteomics.
• Contribute to strategy across drug discovery and early development.

Skills

Translational assays

Primary human cells

Immunology

Flow cytometry

RNA-seq

Education

PhD in Immunology

Postdoctoral experience

Tools

Flow cytometry

qPCR

RNA extraction

Job description

Senior Scientist – Immunology / Translational Research

A leading pharmaceutical company is looking for an experienced Senior Scientist to join its Immunology Research team, working within the Resolution of Inflammation focus area.

This is an exciting opportunity to support the progression and optimisation of therapeutic molecules within early clinical development, generating and analysing preclinical and translational data to support scientific decision-making and patient population selection.

The Role

You will work as part of multidisciplinary project teams, designing and delivering experiments to understand target biology, model pathogenic mechanisms and investigate the mechanisms of action of novel therapeutics.

Key responsibilities will include:

• Developing and running translational in vitro and ex vivo assays
• Working with primary human cells and tissues to develop relevant disease models.
• Using a range of techniques including immunology assays, stromal/tissue-resident cell assays, co-culture, 3D models, imaging, flow cytometry, protein and RNA extraction and analysis.
• Analysing and integrating large, complex datasets from multiple sources.
• Working with Bulk RNA-seq, single-cell RNA-seq, spatial transcriptomics and proteomics datasets.
• Contributing to scientific strategy and decision-making across drug discovery and early development programmes.

About You

• A PhD in immunology, biology or a related discipline, with around 3 years' additional postdoctoral experience.
• A strong technical and biological background in immunology and/or stromal biology.
• Experience working across immune mediated diseases
• Strong practical experience with in vitro and/or ex vivo disease models and primary human cells or tissues.
• An understanding of HTA regulations
• Experience with flow cytometry, immunofluorescence, qPCR etc.
• Experience generating or analysing Bulk RNA-seq, scRNA-seq, spatial transcriptomics and/or proteomics data would be advantageous.
• An understanding of drug discovery and development processes would be desirable.

This position is offered on an initial 12 month contract with potential for extension.

This is an excellent opportunity to join a highly collaborative Immunology Research environment and contribute directly to the development of novel therapeutic approaches in inflammation and immune-mediated disease.

Keywords: inflammation, research, development, in vitro, translational, ex vivo, co-culture, immunology, stromal, HTA, flow cytometry, immunoflourescence, qPCR, RNA-seq, transcriptomics, proteomics, Slough, Windlesham, London, Oxford, Reading, VRS9534SE