Senior Research Associate - 174454

Piper Companies; Cambridge; On-site; GBP 52,000 - 74,000; Full time

Benefits offered by this job

Medical, Dental, Vision

401k

Paid Holidays

PTO (Paid Time Off)

Sick leave as per law

Job summary

Piper Companies in Cambridge, MA is seeking a highly motivated Senior Research Associate II to support the development of innovative cell-based therapies through hands-on stem cell culture, genetic engineering studies, and translational biology programs.

The role requires 3+ years of pluripotent stem cell work, GMP experience, and proficiency with flow cytometry, RT-qPCR, ddPCR, ELISA, and immunostaining; weekend shifts are scheduled.

Qualifications

• 3+ years of hands-on experience with human pluripotent stem cell culture (IPSC), differentiation, and maintenance.
• Experience in regenerative medicine, cell therapy, gene editing, or related therapeutic development fields.
• Must have experience working in a GMP-regulated biotech/biopharmaceutical environment.
• Extensive experience performing techniques such as flow cytometry, RT-qPCR, ddPCR, ELISA, and immunostaining methods.
• Bachelor's or Master's degree in Biology, Cell Biology, Molecular Biology, Biotechnology, Regenerative Medicine, Genetics, or a related scientific discipline.
• Schedule requires weekend work – 40 hours per week (Thurs-Monday Shift or Fri-Tues)

Responsibilities

• Perform routine culture, expansion, maintenance, and differentiation of human stem cells and other mammalian cell lines.
• Support research initiatives involving cellular engineering, gene modification, and evaluation of cellular function in lab and preclinical settings.
• Monitor cell health, growth, sterility, and experimental quality with detailed records.
• Carry out molecular and cellular biology techniques including nucleic acid extraction, cDNA prep, gene expression analysis, and protein assays.
• Conduct experiments using flow cytometry, qPCR, ddPCR, ELISA, immunofluorescence, and related methods.
• Assist in developing, optimizing, and troubleshooting workflows and SOPs.
• Compile, interpret, and present experimental findings using statistical methods.
• Maintain inventory, prepare reagents, monitor supplies, coordinate purchasing of materials and equipment.

Education

Bachelor's or Master's degree in Biology or related field

Tools

Flow Cytometry

RT-qPCR

ddPCR

ELISA

Immunostaining

Western Blot

Job description

Piper Companies is seeking a highly motivated Senior Research Associate II to support the development of innovative cell-based therapies. This role will contribute to stem cell research, genetic engineering studies, and translational biology programs through hands-on laboratory experimentation and data analysis. This role is out of Cambridge, MA.

Responsibilities of the Senior RA II:

• Perform routine culture, expansion, maintenance, and differentiation of human stem cells and other mammalian cell lines.


• Support research initiatives involving cellular engineering, gene modification, and evaluation of cellular function in both laboratory and preclinical settings.


• Monitor cell health, growth characteristics, sterility, and experimental quality while maintaining detailed laboratory records.


• Carry out molecular and cellular biology techniques, including nucleic acid extraction, cDNA preparation, gene expression analysis, and protein-based assays.


• Conduct experiments using technologies such as flow cytometry, quantitative PCR, digital PCR, ELISA, immunofluorescence, and related analytical methods.


• Assist in developing, optimizing, and troubleshooting experimental workflows and standard operating procedures.


• Compile, interpret, and present experimental findings using appropriate statistical and analytical methods.


• Maintain laboratory inventory, prepare reagents, monitor supplies, and coordinate purchasing of laboratory materials and equipment.

Qualifications of the Senior RA II:

• 3+ years of hands-on experience with human pluripotent stem cell culture (IPSC), differentiation, and maintenance


• Experience in regenerative medicine, cell therapy, gene editing, or related therapeutic development fields.


• Must have experience working in a GMP-regulated biotech/biopharmaceutical environment


• Extensive experience performing techniques such as flow cytometry, RT-qPCR, ddPCR, ELISA, and immunostaining methods.


• Bachelor's or Master's degree in Biology, Cell Biology, Molecular Biology, Biotechnology, Regenerative Medicine, Genetics, or a related scientific discipline


• Schedule requires weekend work – 40 hours per week (Thurs-Monday Shift or Fri-Tues)

Compensation for the Senior RA II:

• Salary: $70,000 - $100,000, commensurate with experience


• Comprehensive Benefits: Medical, Dental, Vision 401k, Paid Holidays, PTO (Paid Time Off), Sick leave required as by law

This job opens for applications on 8/12/2026. Applications for this job will be accepted for at least 30 days from the posting date.

Keywords:

Research Associate, Scientist, Senior Research Associate, RA, IPSC, Human Pluripotent, Stem Cell, Cell Culture, Cell Therapy, Regenerative Medicine, Gene Editing, GMP, Good Manufacturing Practice, Pharma, Biotech, Immunostaining, RT-qPCR, qPCR, ddPCR, ELISA, Western Blot, Immunology, Molecular Biology, DNA, RNA, Cell Biology, Associate Scientist, Cellular Engineering, Flow Cytometry, Immunohistochemistry, 3D, 2D, Immunofluorescence, Staining, Aseptic Technique, Process Development, Genetic Engineering, Differentiation, Tissue Culture, Human Stem, Induced Pluripotent Stem Cell, CHO, Pluripotent, Emrbyonic, Immune Cell, Heart cell, Pancreatic Cell, Kidney Cell, Liver Cell, Disease Modeling