Senior In Vitro Pharmacology Investigator

Isomorphic Labs; Greater London; Hybrid; GBP 90,000 - 130,000; Full time

Benefits offered by this job

Hybrid work model

Office 3 days week

Job summary

Isomorphic Labs in London is seeking a hands-on Research Investigator/Senior Research Investigator to lead in vitro pharmacology and biophysics efforts within the Exploratory Sciences Team. You will design and execute biochemical, biophysical and cellular assays to advance novel modalities, working closely with ML and computational biology colleagues.

The role combines wet-lab experimentation with in silico hypothesis building, leveraging LLM agentic workflows and a collaborative,

Qualifications

• BSc, MSc or PhD in a relevant field of biology (Pharmacology, Biochemistry, Biophysics, Cell Biology or a related discipline).
• Strong hands-on expertise in in vitro pharmacology and/or biophysics, including assay development, optimisation and data analysis.
• Experience with novel modalities and data-driven discovery, and enthusiasm for AI-assisted workflows.

Responsibilities

• Design, develop and run biochemical, biophysical (e.g. SPR/GCI, nanoDSF, Spectral Shift, MST) and cellular assays for novel modalities.
• Generate quantitative data on binding kinetics, ternary complex formation, degradation and functional pathway readouts.
• Develop modality-specific cellular assays showing target engagement and functional pathway effects, linking molecular data to therapeutic hypotheses.
• Profile novel chemical matter from in silico design pipelines and interpret results to guide next design cycles.
• Help build and refine screening cascades for internal and partnered programmes.

Skills

In vitro pharmacology

Biophysics

Data analysis

Education

Biology/Pharmacology PhD

Job description

Isomorphic Labs in London is seeking a hands-on Research Investigator/Senior Research Investigator to lead in vitro pharmacology and biophysics efforts within the Exploratory Sciences Team. You will design and execute biochemical, biophysical and cellular assays to advance novel modalities, working closely with ML and computational biology colleagues.

The role combines wet-lab experimentation with in silico hypothesis building, leveraging LLM agentic workflows and a collaborative,