Scientist Analytical Development - Oxford

ZipRecruiter; Oxford; On-site; GBP 40,000 - 70,000; Full time

Job summary

An innovative biotechnology company is seeking a Scientist in Analytical Development to contribute to the characterization of biotherapeutic molecules. This role involves utilizing advanced techniques such as mass spectrometry and HPLC to support drug development processes. The ideal candidate will have a strong background in biochemistry or biotechnology, with at least two years of industry experience. Join a collaborative environment that values scientific excellence and continuous learning, making a significant impact on transformative therapies for patients in need.

Qualifications

• 2+ years in recombinant protein or antibody analytical development.
• Proficiency in bio-pharmaceutical laboratory practices.

Responsibilities

• Characterizing biotherapeutic recombinant T-cell receptor-based molecules.
• Supporting drug substance and product impurity characterization.

Skills

HPLC-based methods

LC-MS method development

Electrophoretic techniques

Chromatographic techniques

Mass spectrometry techniques

Biopharmaceutical laboratory practices

Education

BSc in Biochemistry

MSc in Biotechnology

PhD in related discipline

Job description

Job Description

Scientist Analytical Development - Oxford

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company dedicated to developing and commercializing transformative medicines addressing unmet patient needs in oncology, infectious diseases, and autoimmune diseases. Our R&D leaders are recognized globally for their success in drug development. We foster an environment that encourages interaction among great minds and drives innovation to answer significant scientific questions.

Focused on delivering first-in-class biological therapies, we have developed an innovative soluble TCR platform. Our ImmTAX molecules are precision-engineered drugs that harness the immune system to treat various diseases with high unmet medical need, including cancer, infectious, and autoimmune diseases. At Immunocore, we value our employees as our greatest asset.

We embrace the values of Science, Trust, Respect, Integrity, and Entrepreneurship (STRIDE), creating a collaborative environment where ideas flourish and transformative changes occur. We are committed to developing breakthrough therapies that improve patients' lives, advancing medicine, and supporting our team. Immunocore is an equal opportunity employer dedicated to fostering an inclusive workplace where everyone feels valued, respected, and empowered.

We encourage applications from individuals of all backgrounds, regardless of race, sex, or other protected characteristics.

Role Overview

The successful candidate will characterize biotherapeutic recombinant T-cell receptor-based molecules and related products using protein characterization and mass spectrometry methods. Responsibilities include developing and supporting characterization methods such as peptide mapping (LC-MS/MS) and intact mass spectrometry analysis, as well as contributing to process development and study documentation.

Key Responsibilities

1. Supporting drug substance and drug product impurity characterization and identification.
2. Performing protein sequence analysis and post-translational modification identification, including glycosylation analysis.
3. Supporting process development through characterization of process intermediates.
4. Contributing to method development for ImmTAX and other products.
5. Writing study protocols and reports.
6. Planning experiments, managing deadlines, and advising on risks and deviations.
7. Expanding scientific knowledge through continuous learning and peer mentoring.
8. Maintaining accurate laboratory records and ensuring effective use of equipment.
9. Presenting research findings to colleagues, management, and partners.
10. Adhering to safe laboratory practices according to Immunocore policies.

Person Specification

Experience & Knowledge (Essential)

• At least 2 years of industry experience in recombinant protein or antibody analytical development or QC.
• Experience developing HPLC-based methods for recombinant proteins or antibodies.
• Experience with LC-MS method development.
• Proficiency in bio-pharmaceutical/biochemistry laboratory practices, including buffer and reagent design, routine procedures, and troubleshooting.
• Expertise in electrophoretic, chromatographic, and mass spectrometry techniques.
• Knowledge of assay qualification/validation principles and GMP standards.

Desirable

• Understanding of stability studies and glycosylation analysis.
• Experience in method transfer and external collaborations.
• Conference presentation experience.
• Knowledge supporting clinical trial materials.

Education & Qualifications

• Essential: BSc or MSc in biochemistry, biotechnology, or related field.
• Desirable: PhD in a related discipline.