Safer-by-Design Immune Pathway Scientist

University of Cambridge; Cambridge; On-site; GBP 42,000 - 68,000; Full time

Job summary

The University of Cambridge invites applications for a Research Associate to establish new experimental models to understand how nucleic acid therapeutics activate innate immune signalling. The post sits within a new collaboration between the MRC Toxicology Unit and AstraZeneca R&D, and seeks to identify molecular features and pathways that govern inflammatory or therapeutic responses.

The successful candidate will work at the interface of RNA biology, immunology and toxicology, developing

Qualifications

• PhD in a relevant discipline or close to completion.
• Strong background in innate immunology and RNA biology.
• Experience with organoid/3D culture models and molecular cell biology.

Responsibilities

• Develop experimental models to study nucleic acid therapeutics and innate immune signalling.
• Quantify immune cell contributions using high‑throughput methods.
• Test strategies to modify immune responses to reduce toxicity or enhance efficacy.

Skills

Innate immunology

RNA biology

Organoid/3D culture

High‑throughput analysis

Education

PhD in a relevant discipline

Tools

CRISPR

Job description

The University of Cambridge invites applications for a Research Associate to establish new experimental models to understand how nucleic acid therapeutics activate innate immune signalling. The post sits within a new collaboration between the MRC Toxicology Unit and AstraZeneca R&D, and seeks to identify molecular features and pathways that govern inflammatory or therapeutic responses.

The successful candidate will work at the interface of RNA biology, immunology and toxicology, developing