Research Fellow (Trial Manager, Botswana)

London School of Hygiene & Tropical Medicine; Greater London; On-site; GBP 47,000 - 53,000; Full time

Benefits offered by this job

Pension scheme

Wellbeing days

30 days annual leave (pro rata)

Job summary

London School of Hygiene & Tropical Medicine is seeking a Research Fellow (Trial Manager) to oversee the day-to-day operational management of ADVANCING-CM, a multicentre Phase IIb-III trial in Botswana, Malawi, South Africa and Uganda. The post is based full-time at the coordinating centre in Gaborone with travels to sites.

The successful candidate will hold a postgraduate degree (PhD preferred), with substantial experience in multicentre phase III CTIMPs, trial setup, monitoring and regulatory

Qualifications

• Postgraduate degree in a relevant topic; doctoral degree preferred.
• Experience in multicentre phase III clinical trials (CTIMPs).
• Experience with trial set-up, site initiation, ongoing monitoring and regulatory compliance.

Responsibilities

• Lead day-to-day operational management of multicentre trial sites.
• Oversee trial set-up, regulatory/ethics processes, site initiation and monitoring.
• Ensure data quality, safety reporting and adherence to protocol and GCP.

Skills

Trial management

Clinical research coordination

GCP compliance

Multisite collaboration

Travel readiness

Education

Postgraduate degree

Doctoral degree preferred

Tools

CTIMP knowledge

Trial documentation

Job description

Research Fellow (Trial Manager, Botswana)

Department Department of Clinical Research Salary £46,643 to £52,909per annum pro rata inclusive ClosingDate Thursday 19 November 2026 Reference ITD-CRD-2026-25

The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working in partnership to achieve excellence in public and global health research, education and translation of knowledge into policy and practice.

LSHTM is seeking to appoint a Trial Manager within the Clinical Research Department. The post-holder will be responsible for the day-to-day operational management of ADVANCING-CM, a multi-site phase IIb into phase III randomised clinical trial of adjunctive interferon gamma for HIV-associated cryptococcal meningitis in Botswana, Malawi, South Africa and Uganda. They will work closely with the International Lead Clinician, the experienced senior trial management team and study coordinators at the participating African study sites. The post-holder will be expected to be based full-time at the Trial Coordinating Centre in Gaborone, Botswana for the duration of study recruitment and to travel frequently to the other trial sites. The role will provide operational leadership across trial set-up, regulatory and ethics processes, site initiation and monitoring, trial documentation, data quality, safety-reporting systems and trial governance, ensuring that the study is conducted in accordance with the protocol, Good Clinical Practice (GCP), applicable regulatory requirements and trial procedures.

The successful candidate will have a postgraduate degree, ideally a doctoral degree, in a relevant topic, relevant experience of working on multicentre phase III clinical trials, including Clinical Trials of Investigational Medicinal Products (CTIMPs), experience of trial set-up and site initiation, including preparation and maintenance of essential trial documentation, experience of clinical trial monitoring, including identification and follow-up of monitoring findings and protocol deviations. Further particulars are available in the job description.

The post is full-time 35 hours per week, 1.0 FTE and fixed term until 31 December 2030. The post is funded by Coefficient Giving and is available from 01 January 2027.

The salary will be on the LSHTM salary scale, Grade 6 in the range £46,643 - £52,909 per annum pro rata (inclusive of London Weighting). The post will be subject to the LSHTM terms and conditions of service. Annual leave entitlement is 30 working days per year, pro rata for part time staff. In addition to this there are discretionary "Wellbeing Days". Membership of the Pension Scheme is available. This post is based in Botswana, hosted by the Botswana Harvard Health Partnership Institute in Gaborone with frequent travels to sites in Malawi, Uganda and South Africa.

The London School of Hygiene & Tropical Medicine is committed to being an equal opportunities employer. We believe that when people feel respected and included, they can be more creative, successful, and happier at work. While we have more work to do, we are committed to building an inclusive workplace, a community that everyone feels a part of, which is safe, respectful, supportive and enables all to reach their full potential.