Research Fellow in Host Pathogen Interactions

University of Leeds; Leeds; In loco; GBP 45.000 - 75.000; Tempo pieno

Vantaggi offerti da questo lavoro

Generous pension

Health & wellbeing facilities

Personal development courses

On-site childcare

Shopping discounts

Travel schemes

Descrizione del lavoro

The University of Leeds invites applications for a molecular and cell biologist to study host–pathogen interactions of bunyaviruses. The post is embedded in an international collaboration with virology, immunology, and imaging experts, offering access to state-of-the-art facilities.

You will lead genome-wide CRISPR-Cas9 and haploid cell screening, followed by mechanistic dissection using advanced imaging and functional assays, contributing to high-impact publications.

Competenze

• PhD and postdoctoral experience in host-pathogen interactions and genome-wide screening.
• Proven publication record in high-ranking journals.
• Experience with molecular biology and cell imaging techniques.
• Experience with genome-wide CRISPR-Cas9 and haploid cell screening.
• Ability to work in an international, multidisciplinary collaboration.

Mansioni

• Study host–pathogen interactions of bunyaviruses at the molecular/atomic level in host cells.
• Implement genome-wide CRISPR-Cas9 and haploid cell screening and analyze results.
• Dissect mechanisms using imaging and functional assays.
• Collaborate with virology, immunology, structural biology teams.
• Publish findings in high-profile journals.

Conoscenze

Host-pathogen interactions

Genome-wide screening

Molecular biology

Cell imaging

CRISPR-Cas9

haploid screening

Publication record

Formazione

PhD

Descrizione del lavoro

Are you an ambitious researcher looking for your next challenge? Do you have an established background in host pathogen interactions and genomic screening? Do you want to further your career in one of the UKs leading research intensive Universities?

We have a vacancy for a molecular and cell biologist to study the host-pathogen interactions of a group of viruses known as the bunyaviruses. This appointment is part of an international collaboration involving scientists working in virology, immunology, structural biology, and cutting-edge image analysis. We seek to understand the formation of viral factories by bunyaviruses within host cells at the molecular and atomic level. One specific goal of the project will be to use genome-wide screening and proteomic approaches to define host restriction factors and molecular components essential for the viral life cycle. The work will involve the implementation of genome-wide CRISPR‑Cas9, and haploid cell screening followed by mechanistic dissection via imaging and functional manipulation.

You should have a PhD and post doctorial experience, in host pathogen‑interactions, genome‑wide screening, molecular biology and cell imaging techniques, as well as a proven publication record in high‑ranking journals. The successful candidate will join the thriving research environment within the Faculty of Health and Life Sciences, and have the opportunity to use and gain experience of new state‑of-the-art research facilities in cell biology, molecular virology and cell imaging.

What We Offer In Return

• 26 days holiday plus approx.16 Bank Holidays/days that the University is closed by custom (including Christmas) – That’s 42 days a year!
• Generous pension scheme options plus life assurance.
• Health and Wellbeing: Discounted staff membership options at The Edge, our state-of-the-art Campus gym, with a pool, sauna, climbing wall, cycle circuit, and sports halls.
• Personal Development: Access to courses run by our Organisational Development & Professional Learning team.
• Access to on-site childcare, shopping discounts and travel schemes are also available.

And much more!

To explore the post further or for any queries you may have, please contact:

Dr Martin Stacey, Associate Professor

Email: [e-mail]