Proteomics Mass Spectrometry Investigator

The Methodist Church in Britain; England; On-site; GBP 55,000 - 85,000; Full time

Job summary

The MRC Laboratory of Molecular Biology's Biological Mass Spectrometry and Proteomics Facility seeks an investigator scientist to run quantitative proteomics and maintain mass spectrometers. The role covers labelled and label-free workflows, phosphoproteomics, and HDX/crosslinking MS, with data reporting to facility users.

You will collaborate with the bioinformatician, manage multiple projects, contribute to publications, and train students and postdocs in sample preparation and SOP adherence.

Qualifications

• PhD in a relevant biological subject, analytical chemistry, biochemistry or related field.
• Postdoctoral experience in an MS proteomics facility.
• Proven delivery of proteomics projects.
• Record of presenting at national/international conferences.

Responsibilities

• Prepare samples for quantitative and structural proteomics pipelines.
• Execute quantitative proteomics workflows including labelled, label-free, phosphoproteomics, HDX and crosslinking MS.
• Maintain and troubleshoot mass spectrometers and related instruments with QC.
• Analyse data and communicate findings and experimental advice to facility users.
• Work with the facility bioinformatician on data analysis and database searches.
• Manage multiple projects and provide progress updates to the Facility Head.
• Coordinate with the Facility Head on workflow changes and the facility's strategic direction.
• Contribute to publications and grant applications through data analysis and figures.
• Train students, postdocs and others in sample preparation.
• Keep accurate records per SOPs and good practice.
• Stay up to date with developments in mass spectrometry proteomics.
• Present work at internal seminars and external meetings.

Skills

TMT & SILAC

Label-free workflows

HDX

Crosslinking MS

Protein PTMs

Data analysis

Education

PhD in a relevant biological subject

Tools

Mass spectrometers

Mass spectrometry instruments

Quality control instruments

Job description

The MRC Laboratory of Molecular Biology's Biological Mass Spectrometry and Proteomics Facility seeks an investigator scientist to run quantitative proteomics and maintain mass spectrometers. The role covers labelled and label-free workflows, phosphoproteomics, and HDX/crosslinking MS, with data reporting to facility users.

You will collaborate with the bioinformatician, manage multiple projects, contribute to publications, and train students and postdocs in sample preparation and SOP adherence.